CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018312
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Sec1 family domain-containing protein 1 
Protein Synonyms/Alias
 SLY1 homolog; Sly1p; Syntaxin-binding protein 1-like 2 
Gene Name
 SCFD1 
Gene Synonyms/Alias
 C14orf163; KIAA0917; STXBP1L2; FKSG23 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
63ISPLLSVKELRDMGIubiquitination[1, 2, 3, 4]
126ISAISRSKLEDIANAubiquitination[2, 4]
324YDLTPVDKFWQKHKGubiquitination[1, 3]
330DKFWQKHKGSPFPEVubiquitination[3]
395SLPELLEKKRLIDLHubiquitination[2, 3, 4]
396LPELLEKKRLIDLHTubiquitination[3]
436MSKTTLDKSLLDIISubiquitination[2]
494LNPLQYIKQWKAFTKubiquitination[1]
501KQWKAFTKMASAPASubiquitination[1, 3]
515SYGSTTTKPMGLLSRubiquitination[2, 4]
536QFVMEGVKNLVLKQQubiquitination[2]
541GVKNLVLKQQNLPVTubiquitination[2, 3]
558LDNLMEMKSNPETDDubiquitination[2, 3, 4]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with COG4. Involved in vesicular transport between the endoplasmic reticulum and the Golgi (By similarity). 
Sequence Annotation
 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 303 303 Phosphoserine.  
Keyword
 Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Endoplasmic reticulum; ER-Golgi transport; Golgi apparatus; Membrane; Phosphoprotein; Polymorphism; Protein transport; Reference proteome; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 642 AA 
Protein Sequence
MAAAAAATAA AAASIRERQT VALKRMLNFN VPHIKNSTGE PVWKVLIYDR FGQDIISPLL 60
SVKELRDMGI TLHLLLHSDR DPIPDVPAVY FVMPTEENID RMCQDLRNQL YESYYLNFIS 120
AISRSKLEDI ANAALAASAV TQVAKVFDQY LNFITLEDDM FVLCNQNKEL VSYRAINRPD 180
ITDTEMETVM DTIVDSLFCF FVTLGAVPII RCSRGTAAEM VAVKLDKKLR ENLRDARNSL 240
FTGDTLGAGQ FSFQRPLLVL VDRNIDLATP LHHTWTYQAL VHDVLDFHLN RVNLEESSGV 300
ENSPAGARPK RKNKKSYDLT PVDKFWQKHK GSPFPEVAES VQQELESYRA QEDEVKRLKS 360
IMGLEGEDEG AISMLSDNTA KLTSAVSSLP ELLEKKRLID LHTNVATAVL EHIKARKLDV 420
YFEYEEKIMS KTTLDKSLLD IISDPDAGTP EDKMRLFLIY YISTQQAPSE ADLEQYKKAL 480
TDAGCNLNPL QYIKQWKAFT KMASAPASYG STTTKPMGLL SRVMNTGSQF VMEGVKNLVL 540
KQQNLPVTRI LDNLMEMKSN PETDDYRYFD PKMLRGNDSS VPRNKNPFQE AIVFVVGGGN 600
YIEYQNLVDY IKGKQGKHIL YGCSELFNAT QFIKQLSQLG QK 642 
Gene Ontology
 GO:0005801; C:cis-Golgi network; IDA:UniProtKB.
 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0032580; C:Golgi cisterna membrane; IEA:UniProtKB-SubCell.
 GO:0017119; C:Golgi transport complex; IEA:Compara.
 GO:0005798; C:Golgi-associated vesicle; ISS:UniProtKB.
 GO:0005886; C:plasma membrane; ISS:UniProtKB.
 GO:0019905; F:syntaxin binding; ISS:UniProtKB.
 GO:0006892; P:post-Golgi vesicle-mediated transport; ISS:UniProtKB.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW.
 GO:0060628; P:regulation of ER to Golgi vesicle-mediated transport; ISS:UniProtKB.
 GO:0001666; P:response to hypoxia; IEA:Compara.
 GO:0009636; P:response to toxic substance; IEP:UniProtKB.
 GO:0006890; P:retrograde vesicle-mediated transport, Golgi to ER; ISS:UniProtKB.
 GO:0006904; P:vesicle docking involved in exocytosis; IEA:InterPro. 
Interpro
 IPR027482; Sec-1-like_dom2.
 IPR001619; Sec1-like. 
Pfam
 PF00995; Sec1 
SMART
  
PROSITE
  
PRINTS