CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-040566
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Alpha-2B adrenergic receptor 
Protein Synonyms/Alias
  
Gene Name
 Adra2b 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
350RGQVLLSKNVGVASGubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Cell membrane; Complete proteome; G-protein coupled receptor; Membrane; Receptor; Reference proteome; Transducer; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 453 AA 
Protein Sequence
MSGPAMVHQE PYSVQATAAI ASAITFLILF TIFGNALVIL AVLTSRSLRA PQNLFLVSLA 60
AADILVATLI IPFSLANELL GYWYFWRAWC EVYLALDVLF CTSSIVHLCA ISLDRYWAVS 120
RALEYNSKRT PRRIKCIILT VWLIAAVISL PPLIYKGDQR PEPHGLPQCE LNQEAWYILA 180
SSIGSFFAPC LIMILVYLRI YVIAKRSHCR GLGAKRGSGE GESKKPHPAA GGVPASAKVP 240
TLVSPLSSVG EANGHPKPPR EKEEGETPED PEARALPPNW SALPRSVQDQ KKGTSGATAE 300
KGAEEDEEEV EECEPQTLPA SPASVFNPPL QQPQTSRVLA TLRGQVLLSK NVGVASGQWW 360
RRRTQLSREK RFTFVLAVVI GVFVVCWFPF FFSYSLGAIC PQHCKVPHGL FQFFFWIGYC 420
NSSLNPVIYT IFNQDFRRAF RRILCRQWTQ TGW 453 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0004938; F:alpha2-adrenergic receptor activity; IDA:MGI.
 GO:0051379; F:epinephrine binding; IEA:Compara.
 GO:0071883; P:activation of MAPK activity by adrenergic receptor signaling pathway; IEA:Compara.
 GO:0032148; P:activation of protein kinase B activity; IEA:Compara.
 GO:0001525; P:angiogenesis; IMP:MGI.
 GO:0035625; P:epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway; IEA:Compara.
 GO:0007565; P:female pregnancy; IEA:Compara.
 GO:0000165; P:MAPK cascade; IMP:MGI.
 GO:0045777; P:positive regulation of blood pressure; IEA:Compara.
 GO:0045666; P:positive regulation of neuron differentiation; IEA:Compara.
 GO:0070474; P:positive regulation of uterine smooth muscle contraction; IEA:Compara.
 GO:0003056; P:regulation of vascular smooth muscle contraction; IEA:Compara. 
Interpro
 IPR000207; Adren_rcpt_A2B.
 IPR002233; Adrnrgc_rcpt.
 IPR000276; GPCR_Rhodpsn.
 IPR017452; GPCR_Rhodpsn_7TM. 
Pfam
 PF00001; 7tm_1 
SMART
  
PROSITE
 PS00237; G_PROTEIN_RECEP_F1_1
 PS50262; G_PROTEIN_RECEP_F1_2 
PRINTS
 PR01103; ADRENERGICR.
 PR00559; ADRENRGCA2BR.
 PR00237; GPCRRHODOPSN.