CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018276
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Short-chain dehydrogenase/reductase family 42E member 1 
Protein Synonyms/Alias
  
Gene Name
 SDR42E1 
Gene Synonyms/Alias
 HSPC105 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
96QLNRNLIKEVNVRGTubiquitination[1, 2]
162TKSIAEQKVLEANATubiquitination[1, 2]
318LTRTEVYKTGVTHYFubiquitination[1, 2]
337AKKELGYKAQPFDLQubiquitination[1, 2]
351QEAVEWFKAHGHGRSubiquitination[2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
  
Sequence Annotation
 ACT_SITE 152 152 Proton acceptor (By similarity).
 BINDING 156 156 NAD (By similarity).  
Keyword
 Complete proteome; Membrane; NAD; Oxidoreductase; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 393 AA 
Protein Sequence
MDPKRSQKES VLITGGSGYF GFRLGCALNQ NGVHVILFDI SSPAQTIPEG IKFIQGDIRH 60
LSDVEKAFQD ADVTCVFHIA SYGMSGREQL NRNLIKEVNV RGTDNILQVC QRRRVPRLVY 120
TSTFNVIFGG QVIRNGDESL PYLPLHLHPD HYSRTKSIAE QKVLEANATP LDRGDGVLRT 180
CALRPAGIYG PGEQRHLPRI VSYIEKGLFK FVYGDPRSLV EFVHVDNLVQ AHILASEALR 240
ADKGHIASGQ PYFISDGRPV NNFEFFRPLV EGLGYTFPST RLPLTLVYCF AFLTEMVHFI 300
LGRLYNFQPF LTRTEVYKTG VTHYFSLEKA KKELGYKAQP FDLQEAVEWF KAHGHGRSSG 360
SRDSECFVWD GLLVFLLIIA VLMWLPSSVI LSL 393 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
 GO:0006694; P:steroid biosynthetic process; IEA:InterPro. 
Interpro
 IPR002225; 3Beta_OHSteriod_DH/Estase.
 IPR016040; NAD(P)-bd_dom. 
Pfam
 PF01073; 3Beta_HSD 
SMART
  
PROSITE
  
PRINTS