CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-002600
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Lethal(2) giant larvae protein 
Protein Synonyms/Alias
  
Gene Name
 l(2)gl 
Gene Synonyms/Alias
 CG2671 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
21ADRHRLQKDLFAYRKacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 
Functional Description
 Essential for the development of polarized epithelia and for cell polarity associated with asymmetric cell division of neuroblasts during development. Isoform p78 has an essential role in control of cell proliferation and differentiation during development and could act as tumor suppressor. Isoform p217 has an accessory function in this respect. 
Sequence Annotation
 REPEAT 39 72 WD 1.
 REPEAT 82 128 WD 2.
 REPEAT 131 167 WD 3.
 REPEAT 189 223 WD 4.
 REPEAT 231 263 WD 5.
 REPEAT 278 320 WD 6.
 REPEAT 328 358 WD 7.
 REPEAT 380 464 WD 8.
 REPEAT 513 594 WD 9.
 REPEAT 603 664 WD 10.
 REPEAT 708 778 WD 11.
 REPEAT 787 832 WD 12.
 REPEAT 837 927 WD 13.
 REPEAT 941 964 WD 14.
 MOD_RES 473 473 Phosphoserine.
 MOD_RES 484 484 Phosphoserine.
 MOD_RES 679 679 Phosphoserine.
 MOD_RES 808 808 Phosphoserine.
 MOD_RES 869 869 Phosphoserine.
 MOD_RES 876 876 Phosphoserine.
 MOD_RES 887 887 Phosphoserine.
 MOD_RES 889 889 Phosphoserine.
 MOD_RES 893 893 Phosphoserine.
 MOD_RES 1013 1013 Phosphoserine.  
Keyword
 Alternative splicing; Cell cycle; Cell membrane; Complete proteome; Developmental protein; Exocytosis; Extracellular matrix; Membrane; Phosphoprotein; Reference proteome; Repeat; Secreted; Tumor suppressor; WD repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1161 AA 
Protein Sequence
MLKFIRGKGQ QPSADRHRLQ KDLFAYRKTA QHGFPHKPSA LAYDPVLKLM AIGTQTGALK 60
VFGQPGVELY GQHTLLNNSA SELNVQLLEW VYGTGRILSL TAANQLILWE PVGATLLPIK 120
TLPFDGKLKK VSSLCCSLSK DLLWIGTEGG NIYQLDLHTF TIKEPVIYHD VVLEQVPPAY 180
KLNPGAIESI RQLPNSPSKL LVAYNRGLCV LWDFESASVQ RAYIAPGHGQ SVGLTVNFEG 240
SEFTWYHADG SYATWSIDNP EPPSNVNYVP YGPDPCKSIN RLYKGKRRSN DVIVFSGGMP 300
RSAYGDHNCV SVHASDGHKV CLDFTSKVID FFVTFENNRD VAEVLVVLLE EELCAYDLTD 360
PNICAIKAPY LHSVHASAVT CNYLASEVVQ SVYESILRAG DEQDIDYSNI SWPITGGTLP 420
DNLEESVEED ATKLYEILLT GHEDGSVKFW DCTGVLLKPI YNFKTSSIFG SESDFRDDAA 480
ADMSAEQVDE GEPPFRKSGL FDPYSDDPRL AVKKIAFCPK TGQLIVGGTA GQIVIADFID 540
LPEKVSLKYI SMNLVSDRDG FVWKGHDQLN VRSNLLDGEA IPTTERGVNI SGVLQVLPPA 600
SITCMALEAS WGLVSGGTAH GLVLFDFKNF VPVFHRCTLN PNDLTGAGEQ LSRRKSFKKS 660
LRESFRKLRK GRSTRTNQSN QVPTTLEARP VERQIEARCA DDGLGSMVRC LLFAKTYVTN 720
VNITSPTLWS ATNASTVSVF LLHLPPAQTA ATAVPSASGN APPHMPRRIS AQLAKEIQLK 780
HRAPVVGISI FDQAGSPVDQ LNAGENGSPP HRVLIASEEQ FKVFSLPQLK PINKYKLTAN 840
EGARIRRIHF GSFSCRISPE TLQSMHGCSP TKSTRSHGDG EADPNISGSL AVSRGDVYNE 900
TALICLTNMG DIMVLSVPEL KRQLNAAAVR REDINGVSSL CFTNSGEALY MMSSSELQRI 960
ALATSRVVQP TGVVPVEPLE NEESVLEEND AENNKETYAC DEVVNTYEIK NPSGISICTR 1020
PAEENVGRNS VQQVNGVNIS NSPNQANETI SSSIGDITVD SVRDHLNMTT TTLCSINTEE 1080
TIGRLSVLST QTNKASTTVN MSEIPNINIS NLEDLESKRN TTETSTSSVV IKSIITNISH 1140
EKTNGDNKIG TPKTAPEESQ F 1161 
Gene Ontology
 GO:0016327; C:apicolateral plasma membrane; IDA:FlyBase.
 GO:0016323; C:basolateral plasma membrane; TAS:FlyBase.
 GO:0030863; C:cortical cytoskeleton; IDA:FlyBase.
 GO:0005829; C:cytosol; TAS:FlyBase.
 GO:0005578; C:proteinaceous extracellular matrix; IDA:FlyBase.
 GO:0005920; C:smooth septate junction; IDA:FlyBase.
 GO:0008021; C:synaptic vesicle; NAS:FlyBase.
 GO:0045159; F:myosin II binding; IGI:FlyBase.
 GO:0030036; P:actin cytoskeleton organization; IMP:FlyBase.
 GO:0045167; P:asymmetric protein localization involved in cell fate determination; IMP:FlyBase.
 GO:0045175; P:basal protein localization; IMP:FlyBase.
 GO:0035212; P:cell competition in a multicellular organism; IMP:FlyBase.
 GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
 GO:0035293; P:chitin-based larval cuticle pattern formation; IMP:FlyBase.
 GO:0007391; P:dorsal closure; TAS:FlyBase.
 GO:0035072; P:ecdysone-mediated induction of salivary gland cell autophagic cell death; IMP:FlyBase.
 GO:0048730; P:epidermis morphogenesis; IMP:FlyBase.
 GO:0090163; P:establishment of epithelial cell planar polarity; IMP:FlyBase.
 GO:0045200; P:establishment of neuroblast polarity; TAS:FlyBase.
 GO:0045184; P:establishment of protein localization; IMP:FlyBase.
 GO:0045197; P:establishment or maintenance of epithelial cell apical/basal polarity; NAS:FlyBase.
 GO:0016332; P:establishment or maintenance of polarity of embryonic epithelium; TAS:FlyBase.
 GO:0016334; P:establishment or maintenance of polarity of follicular epithelium; IGI:FlyBase.
 GO:0016336; P:establishment or maintenance of polarity of larval imaginal disc epithelium; TAS:FlyBase.
 GO:0051668; P:localization within membrane; IMP:FlyBase.
 GO:0001738; P:morphogenesis of a polarized epithelium; TAS:FlyBase.
 GO:0007406; P:negative regulation of neuroblast proliferation; IMP:FlyBase.
 GO:0045746; P:negative regulation of Notch signaling pathway; IGI:FlyBase.
 GO:0007314; P:oocyte anterior/posterior axis specification; IMP:FlyBase.
 GO:0016325; P:oocyte microtubule cytoskeleton organization; IMP:FlyBase.
 GO:0051726; P:regulation of cell cycle; NAS:FlyBase.
 GO:0008360; P:regulation of cell shape; NAS:FlyBase.
 GO:0007423; P:sensory organ development; IMP:FlyBase.
 GO:0019991; P:septate junction assembly; TAS:FlyBase.
 GO:0016082; P:synaptic vesicle priming; NAS:FlyBase.
 GO:0007179; P:transforming growth factor beta receptor signaling pathway; IMP:FlyBase. 
Interpro
 IPR000664; Lethal2_giant.
 IPR013905; Lgl_C.
 IPR013577; LLGL2.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR017986; WD40_repeat_dom. 
Pfam
 PF08596; Lgl_C
 PF08366; LLGL 
SMART
 SM00320; WD40 
PROSITE
 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 
PRINTS
 PR00962; LETHAL2GIANT.