CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-007458
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 ETS translocation variant 5 
Protein Synonyms/Alias
 Ets-related protein ERM 
Gene Name
 ETV5 
Gene Synonyms/Alias
 ERM 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
89APPPTKIKRELHSPSsumoylation[1, 2, 3]
263PPPPQGFKQEYHDPLsumoylation[1, 2]
293FQSPMGIKQEPRDYCsumoylation[1, 2]
350ERLEGKVKQEPTMYRsumoylation[1]
Reference
 [1] SUMO modification of the Ets-related transcription factor ERM inhibits its transcriptional activity.
 Degerny C, Monte D, Beaudoin C, Jaffray E, Portois L, Hay RT, de Launoit Y, Baert JL.
 J Biol Chem. 2005 Jul 1;280(26):24330-8. [PMID: 15857832]
 [2] ERM transcription factor contains an inhibitory domain which functions in sumoylation-dependent manner.
 Degerny C, de Launoit Y, Baert JL.
 Biochim Biophys Acta. 2008 Mar;1779(3):183-94. [PMID: 18243147]
 [3] The transactivation function of the Pea3 subfamily Ets transcription factors is regulated by sumoylation.
 Bojović BB, Hassell JA.
 DNA Cell Biol. 2008 Jun;27(6):289-305. [PMID: 18447755] 
Functional Description
 Binds to DNA sequences containing the consensus nucleotide core sequence GGAA. 
Sequence Annotation
 DNA_BIND 368 448 ETS.  
Keyword
 Complete proteome; DNA-binding; Nucleus; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 510 AA 
Protein Sequence
MDGFYDQQVP FMVPGKSRSE ECRGRPVIDR KRKFLDTDLA HDSEELFQDL SQLQEAWLAE 60
AQVPDDEQFV PDFQSDNLVL HAPPPTKIKR ELHSPSSELS SCSHEQALGA NYGEKCLYNY 120
CAYDRKPPSG FKPLTPPTTP LSPTHQNPLF PPPQATLPTS GHAPAAGPVQ GVGPAPAPHS 180
LPEPGPQQQT FAVPRPPHQP LQMPKMMPEN QYPSEQRFQR QLSEPCHPFP PQPGVPGDNR 240
PSYHRQMSEP IVPAAPPPPQ GFKQEYHDPL YEHGVPGMPG PPAHGFQSPM GIKQEPRDYC 300
VDSEVPNCQS SYMRGGYFSS SHEGFSYEKD PRLYFDDTCV VPERLEGKVK QEPTMYREGP 360
PYQRRGSLQL WQFLVTLLDD PANAHFIAWT GRGMEFKLIE PEEVARRWGI QKNRPAMNYD 420
KLSRSLRYYY EKGIMQKVAG ERYVYKFVCD PDALFSMAFP DNQRPFLKAE SECHLSEEDT 480
LPLTHFEDSP AYLLDMDRCS SLPYAEGFAY 510 
Gene Ontology
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IDA:UniProtKB.
 GO:0044212; F:transcription regulatory region DNA binding; IDA:UniProtKB.
 GO:0007610; P:behavior; IEA:Compara.
 GO:0034599; P:cellular response to oxidative stress; IDA:UniProtKB.
 GO:0048133; P:male germ-line stem cell division; IEA:Compara.
 GO:0007274; P:neuromuscular synaptic transmission; IEA:Compara.
 GO:0060252; P:positive regulation of glial cell proliferation; IEA:Compara.
 GO:0045666; P:positive regulation of neuron differentiation; IEA:Compara.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; IEA:Compara.
 GO:0060762; P:regulation of branching involved in mammary gland duct morphogenesis; IEA:Compara.
 GO:0050807; P:regulation of synapse organization; IEA:Compara.
 GO:0071340; P:skeletal muscle acetylcholine-gated channel clustering; IEA:Compara. 
Interpro
 IPR000418; Ets_dom.
 IPR006715; ETS_PEA3_N.
 IPR011991; WHTH_DNA-bd_dom. 
Pfam
 PF00178; Ets
 PF04621; ETS_PEA3_N 
SMART
 SM00413; ETS 
PROSITE
 PS00345; ETS_DOMAIN_1
 PS00346; ETS_DOMAIN_2
 PS50061; ETS_DOMAIN_3 
PRINTS
 PR00454; ETSDOMAIN.