| Tag | Content |
|---|
| CPLM ID | CPLM-005141 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Transcriptional regulator URE2 |
Protein Synonyms/Alias | |
Gene Name | URE2 |
Gene Synonyms/Alias | YNL229C; N1165 |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 104 | VEYSRITKFFQEQPL | ubiquitination | [1] |
|
Reference | [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation. Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J. Nat Methods. 2013 Jul;10(7):676-82. [ PMID: 23749301] |
Functional Description | Plays an important role in nitrogen catabolite repression. Down-regulates the expression of many genes involved in nitrogen utilization by inhibiting the GATA transcriptional activators GLN3 and GAT1. Under good nitrogen conditions, binds to the phosphorylated forms of GLN3 and GAT1 and sequesters them in the cytoplasm, preventing transcription of genes expressed upon nitrogen limitation. Has glutathione peroxidase activity in both native and fibrillar form. |
Sequence Annotation | DOMAIN 112 196 GST N-terminal.
DOMAIN 205 354 GST C-terminal.
REGION 1 89 Prion domain (PrD).
REGION 164 165 Glutathione binding.
REGION 180 181 Glutathione binding.
BINDING 124 124 Glutathione.
BINDING 151 151 Glutathione. |
Keyword | 3D-structure; Amyloid; Complete proteome; Cytoplasm; Nitrate assimilation; Prion; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 354 AA |
Protein Sequence | MMNNNGNQVS NLSNALRQVN IGNRNSNTTT DQSNINFEFS TGVNNNNNNN SSSNNNNVQN 60
NNSGRNGSQN NDNENNIKNT LEQHRQQQQA FSDMSHVEYS RITKFFQEQP LEGYTLFSHR 120
SAPNGFKVAI VLSELGFHYN TIFLDFNLGE HRAPEFVSVN PNARVPALID HGMDNLSIWE 180
SGAILLHLVN KYYKETGNPL LWSDDLADQS QINAWLFFQT SGHAPMIGQA LHFRYFHSQK 240
IASAVERYTD EVRRVYGVVE MALAERREAL VMELDTENAA AYSAGTTPMS QSRFFDYPVW 300
LVGDKLTIAD LAFVPWNNVV DRIGINIKIE FPEVYKWTKH MMRRPAVIKA LRGE 354 |
Gene Ontology | GO:0005829; C:cytosol; IDA:SGD. GO:0004602; F:glutathione peroxidase activity; IDA:SGD. GO:0051219; F:phosphoprotein binding; IDA:SGD. GO:0003714; F:transcription corepressor activity; IGI:SGD. GO:0042994; P:cytoplasmic sequestering of transcription factor; IMP:SGD. GO:0042128; P:nitrate assimilation; IEA:UniProtKB-KW. GO:0032447; P:protein urmylation; IMP:SGD. GO:0006808; P:regulation of nitrogen utilization; IMP:SGD. GO:0010044; P:response to aluminum ion; IMP:SGD. |
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Pfam | |
SMART | |
PROSITE | |
PRINTS | |