UniProt Accession

 COFA1_HUMAN; P39059; Q5T6J4; Q9UDC5; Q9Y4W4 

Genbank Protein ID

 L25286; L25280; L25281; L25282; L25283; L25284; L25285; AF052956; AF052957; AF052958; AF052959; AF052960; AF052961; AF052962; AF052963; AF052964; AF052965; AF052966; AF052967; AF052968; AF052969; AF052970; AF052971; AF052972; AF052973; AF052974; AF052975; AL136084; AL354923; AL354923; AL136084; D21230; L01697 

Genbank Nucleotide ID

 AAA58429.1; AAC78500.1; AAC78500.1; AAC78500.1; AAC78500.1; AAC78500.1; AAC78500.1; AAC78500.1; AAC78500.1; AAC78500.1; AAC78500.1; AAC78500.1; AAC78500.1; AAC78500.1; AAC78500.1; AAC78500.1; AAC78500.1; AAC78500.1; AAC78500.1; AAC78500.1; AAC78500.1; AAC78500.1; AAC78500.1; AAC78500.1; AAC78500.1; AAC78500.1; AAC78500.1; CAI17044.2; CAI17044.2; CAI12548.2; CAI12548.2; BAA04762.1 

Protein Name

 Collagen alpha-1(XV) chain 

Protein Synonyms/Alias

 Restin; Endostatin-XV; Related to endostatin; Restin-I; Restin-2; Restin-II; Restin-3; Restin-III; Restin-4; Restin-IV 

Gene Name

 COL15A1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
1239	RADFQCFKQARAAGL	ubiquitination	[1]
1360	ASPLSTGKILDQKAY	ubiquitination	[1]

Reference

 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 

Functional Description

 Structural protein that stabilizes microvessels and muscle cells, both in heart and in skeletal muscle. 

Sequence Annotation

 DOMAIN 66 249 Laminin G-like.
 REPEAT 358 408 1.
 REPEAT 409 459 2.
 REPEAT 460 509 3.
 REPEAT 510 555 4.
 DOMAIN 619 680 Collagen-like 1.
 DOMAIN 681 731 Collagen-like 2.
 DOMAIN 823 865 Collagen-like 3.
 DOMAIN 879 927 Collagen-like 4.
 REGION 229 555 Nonhelical region 1 (NC1).
 REGION 358 555 4 X tandem repeats.
 REGION 556 573 Triple-helical region 1 (COL1).
 REGION 574 618 Nonhelical region 2 (NC2).
 REGION 619 732 Triple-helical region 2 (COL2).
 REGION 733 763 Nonhelical region 3 (NC3).
 REGION 764 798 Triple-helical region 3 (COL3).
 REGION 799 822 Nonhelical region 4 (NC4).
 REGION 823 867 Triple-helical region 4 (COL4).
 REGION 868 878 Nonhelical region 5 (NC5).
 REGION 879 949 Triple-helical region 5 (COL5).
 REGION 950 983 Nonhelical region 6 (NC6).
 REGION 984 1013 Triple-helical region 6 (COL6).
 REGION 1014 1027 Nonhelical region 7 (NC7).
 REGION 1028 1045 Triple-helical region 7 (COL7).
 REGION 1046 1052 Nonhelical region 8 (NC8).
 REGION 1053 1107 Triple-helical region 8 (COL8).
 REGION 1108 1117 Nonhelical region 9 (NC9).
 REGION 1118 1132 Triple-helical region 9 (COL9).
 REGION 1133 1388 Nonhelical region 10 (NC10).
 CARBOHYD 265 265 O-linked (GalNAc...).
 CARBOHYD 306 306 N-linked (GlcNAc...) (Potential).
 CARBOHYD 324 324 N-linked (GlcNAc...) (Potential).
 CARBOHYD 687 687 N-linked (GlcNAc...) (Potential).
 CARBOHYD 807 807 N-linked (GlcNAc...) (Potential).
 CARBOHYD 814 814 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1046 1046 N-linked (GlcNAc...) (Potential).
 DISULFID 1237 1377
 DISULFID 1339 1369  

Keyword

 3D-structure; Angiogenesis; Cell adhesion; Collagen; Complete proteome; Developmental protein; Differentiation; Direct protein sequencing; Disulfide bond; Extracellular matrix; Glycoprotein; Hydroxylation; Polymorphism; Reference proteome; Repeat; Secreted; Signal. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 1388 AA 

Protein Sequence

Gene Ontology

 GO:0005604; C:basement membrane; IEA:Compara.
 GO:0005582; C:collagen type XV; TAS:UniProtKB.
 GO:0005788; C:endoplasmic reticulum lumen; TAS:Reactome.
 GO:0005615; C:extracellular space; IDA:BHF-UCL.
 GO:0016021; C:integral to membrane; NAS:UniProtKB.
 GO:0005201; F:extracellular matrix structural constituent; IC:UniProtKB.
 GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.
 GO:0007155; P:cell adhesion; IC:UniProtKB.
 GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
 GO:0030574; P:collagen catabolic process; TAS:Reactome.
 GO:0022617; P:extracellular matrix disassembly; TAS:Reactome.
 GO:0007165; P:signal transduction; NAS:UniProtKB. 

Interpro

 IPR016186; C-type_lectin-like.
 IPR016187; C-type_lectin_fold.
 IPR008160; Collagen.
 IPR010515; Collagenase_NC10/endostatin.
 IPR008985; ConA-like_lec_gl_sf.
 IPR001791; Laminin_G. 

Pfam

 PF01391; Collagen
 PF06482; Endostatin 

SMART

 SM00282; LamG
 SM00210; TSPN 

PROSITE

 PS50025; LAM_G_DOMAIN 

PRINTS