CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022772
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Transmembrane protein 176B 
Protein Synonyms/Alias
 Protein LR8 
Gene Name
 Tmem176b 
Gene Synonyms/Alias
 Clast1; Lr8 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
44LGAVGSLKKFLSWPQubiquitination[1]
45GAVGSLKKFLSWPQAubiquitination[1]
243NEEESERKLLDGHPAubiquitination[1]
256PAPASPAKEKIPAILubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 May play a role in the process of maturation of dendritic cells (By similarity). Required for the development of cerebellar granule cells. 
Sequence Annotation
 MOD_RES 253 253 Phosphoserine.  
Keyword
 Complete proteome; Differentiation; Membrane; Nucleus; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 263 AA 
Protein Sequence
MVQSTVTVNG VKVASTHPQS AHISIHIHQK SALEQLLGAV GSLKKFLSWP QARIHYGQLS 60
LGVTQILLGL VSCALGVCLY FGPWTELCAF GCAFWSGSVA ILAGVGTIVH EKRQGKLSGQ 120
VSCLLLLACI ATAAAATVLG VNSLIRQTSV PYYVEIFSTC NPLQSSMDPG YGTVRYSDDS 180
DWKTERCREY LNMMMNLFLA FCIMLTVVCI LEIVVSVASL GLSLRSMYGR SSQALNEEES 240
ERKLLDGHPA PASPAKEKIP AIL 263 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
 GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
 GO:2001199; P:negative regulation of dendritic cell differentiation; IMP:MGI. 
Interpro
 IPR007237; CD20-like.
 IPR009281; LR8. 
Pfam
 PF04103; CD20 
SMART
  
PROSITE
  
PRINTS