UniProt Accession

 RDH11_MOUSE; Q9QYF1; Q3UXM9; Q9D0U5 

Genbank Protein ID

 AB035959; AY039032; AF474027; AK004413; AK135443; BC018261 

Genbank Nucleotide ID

 BAA88521.1; AAK91516.1; AAL79910.1; BAB23296.1; BAE22534.1; AAH18261.1 

Protein Name

 Retinol dehydrogenase 11 

Protein Synonyms/Alias

 Androgen-regulated short-chain dehydrogenase/reductase 1; Cell line MC/9.IL4-derived protein 1; M42C60; Prostate short-chain dehydrogenase/reductase 1; Retinal reductase 1; RalR1; Short-chain aldehyde dehydrogenase; SCALD 

Gene Name

 Rdh11 

Gene Synonyms/Alias

 Arsdr1; Mdt1; Psdr1 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
52	GANTGIGKETAKDLA	ubiquitination	[1]
56	GIGKETAKDLAQRGA	ubiquitination	[1]
74	LACRDVDKGELAARE	acetylation	[2]
102	KLDLADTKSIRAFAK	ubiquitination	[1, 3]
109	KSIRAFAKDFLAEEK	ubiquitination	[1]
116	KDFLAEEKHLHLLIN	ubiquitination	[1]
211	LANILFTKELAKRLK	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [3] BTB-ZF factors recruit the E3 ligase cullin 3 to regulate lymphoid effector programs.
 Mathew R, Seiler MP, Scanlon ST, Mao AP, Constantinides MG, Bertozzi-Villa C, Singer JD, Bendelac A.
 Nature. 2012 Nov 22;491(7425):618-21. [PMID: 23086144] 

Functional Description

 Exhibits an oxidoreductive catalytic activity towards retinoids. Most efficient as an NADPH-dependent all-trans-retinal reductase. Also involved in the metabolism of short-chain aldehydes. 

Sequence Annotation

 NP_BIND 45 51 NADP (By similarity).
 ACT_SITE 199 199 Proton acceptor (By similarity).
 BINDING 174 174 Substrate (By similarity).
 MOD_RES 109 109 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Alternative splicing; Complete proteome; Endoplasmic reticulum; Membrane; NADP; Oxidoreductase; Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 316 AA 

Protein Sequence

Gene Ontology

 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005622; C:intracellular; ISS:UniProtKB.
 GO:0001917; C:photoreceptor inner segment; IDA:MGI.
 GO:0052650; F:NADP-retinol dehydrogenase activity; ISO:MGI.
 GO:0004745; F:retinol dehydrogenase activity; ISS:UniProtKB.
 GO:0016062; P:adaptation of rhodopsin mediated signaling; IMP:MGI.
 GO:0042574; P:retinal metabolic process; ISO:MGI.
 GO:0042572; P:retinol metabolic process; ISS:UniProtKB. 

Interpro

 IPR002198; DH_sc/Rdtase_SDR.
 IPR002347; Glc/ribitol_DH.
 IPR016040; NAD(P)-bd_dom. 

Pfam

 PF00106; adh_short 

SMART

  

PROSITE

 PS00061; ADH_SHORT 

PRINTS

 PR00081; GDHRDH.
 PR00080; SDRFAMILY.