CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-008587
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Importin subunit beta-5 
Protein Synonyms/Alias
 114 kDa karyopherin; Karyopherin subunit beta-5; Karyopherin-114 
Gene Name
 KAP114 
Gene Synonyms/Alias
 YGL241W; HRC1004 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
909QLITSDIKQEVVNANsumoylation[1]
Reference
 [1] Sumoylation regulates Kap114-mediated nuclear transport.
 Rothenbusch U, Sawatzki M, Chang Y, Caesar S, Schlenstedt G.
 EMBO J. 2012 May 30;31(11):2461-72. [PMID: 22562154] 
Functional Description
 Required for nuclear protein import and mediates docking of import substrate to distinct nucleoporins. Serves a receptor for nuclear localization signals. Mediates the nuclear import of TATA-binding protein (TBP) and of histones H2A and H2B. 
Sequence Annotation
 DOMAIN 21 100 Importin N-terminal.  
Keyword
 Complete proteome; Cytoplasm; mRNA transport; Nuclear pore complex; Nucleus; Protein transport; Reference proteome; Translocation; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1004 AA 
Protein Sequence
MDINELIIGA QSADKHTREV AETQLLQWCD SDASQVFKAL ANVALQHEAS LESRQFALLS 60
LRKLITMYWS PGFESYRSTS NVEIDVKDFI REVLLKLCLN DNENTKIKNG ASYCIVQISA 120
VDFPDQWPQL LTVIYDAISH QHSLNAMSLL NEIYDDVVSE EMFFEGGIGL ATMEIVFKVL 180
NTETSTLIAK IAALKLLKAC LLQMSSHNEY DEASRKSFVS QCLATSLQIL GQLLTLNFGN 240
VDVISQLKFK SIIYENLVFI KNDFSRKHFS SELQKQFKIM AIQDLENVTH INANVETTES 300
EPLLETVHDC SIYIVEFLTS VCTLQFSVEE MNKIITSLTI LCQLSSETRE IWTSDFNTFV 360
SKETGLAASY NVRDQANEFF TSLPNPQLSL IFKVVSNDIE HSTCNYSTLE SLLYLLQCIL 420
LNDDEITGEN IDQSLQILIK TLENILVSQE IPELILARAI LTIPRVLDKF IDALPDIKPL 480
TSAFLAKSLN LALKSDKELI KSATLIAFTY YCYFAELDSV LGPEVCSETQ EKVIRIINQV 540
SSDAEEDTNG ALMEVLSQVI SYNPKEPHSR KEILQAEFHL VFTISSEDPA NVQVVVQSQE 600
CLEKLLDNIN MDNYKNYIEL CLPSFINVLD SNNANNYRYS PLLSLVLEFI TVFLKKKPND 660
GFLPDEINQY LFEPLAKVLA FSTEDETLQL ATEAFSYLIF NTDTRAMEPR LMDIMKVLER 720
LLSLEVSDSA AMNVGPLVVA IFTRFSKEIQ PLIGRILEAV VVRLIKTQNI STEQNLLSVL 780
CFLTCNDPKQ TVDFLSSFQI DNTDALTLVM RKWIEAFEVI RGEKRIKENI VALSNLFFLN 840
DKRLQKVVVN GNLIPYEGDL IITRSMAKKM PDRYVQVPLY TKIIKLFVSE LSFQSKQPNP 900
EQLITSDIKQ EVVNANKDDD NDDWEDVDDV LDYDKLKEYI DDDVDEEADD DSDDITGLMD 960
VKESVVQLLV RFFKEVASKD VSGFHCIYET LSDSERKVLS EALL 1004 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:SGD.
 GO:0016021; C:integral to membrane; ISM:SGD.
 GO:0005643; C:nuclear pore; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IDA:SGD.
 GO:0008565; F:protein transporter activity; IMP:SGD.
 GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
 GO:0042991; P:transcription factor import into nucleus; IMP:SGD. 
Interpro
 IPR011989; ARM-like.
 IPR016024; ARM-type_fold.
 IPR001494; Importin-beta_N. 
Pfam
 PF03810; IBN_N 
SMART
 SM00913; IBN_N 
PROSITE
 PS50166; IMPORTIN_B_NT 
PRINTS