CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031418
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Delta-like protein 
Protein Synonyms/Alias
  
Gene Name
 JAG1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
569YDEGDAFKCMCPGGWubiquitination[1]
964REQLNQIKNPIEKHGubiquitination[1, 2, 3]
969QIKNPIEKHGANTVPubiquitination[1]
978GANTVPIKDYENKNSubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 Putative Notch ligand involved in the mediation of Notch signaling (By similarity). 
Sequence Annotation
  
Keyword
 Complete proteome; Developmental protein; Disulfide bond; EGF-like domain; Membrane; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1059 AA 
Protein Sequence
MINPSRQWQT LKQNTGVAHF EYQIRVTCDD YYYGFGCNKF CRPRDDFFGH YACDQNGNKT 60
CMEGWMGPEC NRAICRQGCS PKHGSCKLPG DCRCQYGWQG LYCDKCIPHP GCVHGICNEP 120
WQCLCETNWG GQLCDKDLNY CGTHQPCLNG GTCSNTGPDK YQCSCPEGYS GPNCEIAEHA 180
CLSDPCHNRG SCKETSLGFE CECSPGWTGP TCSTNIDDCS PNNCSHGGTC QDLVNGFKCV 240
CPPQWTGKTC QLDANECEAK PCVNAKSCKN LIASYYCDCL PGWMGQNCDI NINDCLGQCQ 300
NDASCRDLVN GYRCICPPGY AGDHCERDID ECASNPCLNG GHCQNEINRF QCLCPTGFSG 360
NLCQLDIDYC EPNPCQNGAQ CYNRASDYFC KCPEDYEGKN CSHLKDHCRT TPCEVIDSCT 420
VAMASNDTPE GVRYISSNVC GPHGKCKSQS GGKFTCDCNK GFTGTYCHEN INDCESNPCR 480
NGGTCIDGVN SYKCICSDGW EGAYCETNIN DCSQNPCHNG GTCRDLVNDF YCDCKNGWKG 540
KTCHSRDSQC DEATCNNGGT CYDEGDAFKC MCPGGWEGTT CNIARNSSCL PNPCHNGGTC 600
VVNGESFTCV CKEGWEGPIC AQNTNDCSPH PCYNSGTCVD GDNWYRCECA PGFAGPDCRI 660
NINECQSSPC AFGATCVDEI NGYRCVCPPG HSGAKCQEVS GRPCITMGSV IPDGAKWDDD 720
CNTCQCLNGR IACSKVWCGP RPCLLHKGHS ECPSGQSCIP ILDDQCFVHP CTGVGECRSS 780
SLQPVKTKCT SDSYYQDNCA NITFTFNKEM MSPGLTTEHI CSELRNLNIL KNVSAEYSIY 840
IACEPSPSAN NEIHVAISAE DIRDDGNPIK EITDKIIDLV SKRDGNSSLI AAVAEVRVQR 900
RPLKNRTDFL VPLLSSVLTV AWICCLVTAF YWCLRKRRKP GSHTHSASED NTTNNVREQL 960
NQIKNPIEKH GANTVPIKDY ENKNSKMSKI RTHNSEVEED DMDKHQQKAR FAKQPAYTLV 1020
DREEKPPNGT PTKHPNWTNK QDNRDLESAQ SLNRMEYIV 1059 
Gene Ontology
 GO:0045177; C:apical part of cell; IEA:Compara.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0035909; P:aorta morphogenesis; IEA:Compara.
 GO:0042491; P:auditory receptor cell differentiation; IEA:Compara.
 GO:0061309; P:cardiac neural crest cell development involved in outflow tract morphogenesis; IEA:Compara.
 GO:0003215; P:cardiac right ventricle morphogenesis; IEA:Compara.
 GO:0060411; P:cardiac septum morphogenesis; IEA:Compara.
 GO:0072017; P:distal tubule development; IEA:Compara.
 GO:0061444; P:endocardial cushion cell development; IEA:Compara.
 GO:0072070; P:loop of Henle development; IEA:Compara.
 GO:0002011; P:morphogenesis of an epithelial sheet; IEA:Compara.
 GO:0045599; P:negative regulation of fat cell differentiation; IEA:Compara.
 GO:0045665; P:negative regulation of neuron differentiation; IEA:Compara.
 GO:0061314; P:Notch signaling involved in heart development; IEA:Compara.
 GO:0045639; P:positive regulation of myeloid cell differentiation; IEA:Compara.
 GO:0045747; P:positive regulation of Notch signaling pathway; IEA:Compara.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0032495; P:response to muramyl dipeptide; IEA:Compara. 
Interpro
 IPR001774; DSL.
 IPR000742; EG-like_dom.
 IPR001881; EGF-like_Ca-bd.
 IPR013032; EGF-like_CS.
 IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
 IPR018097; EGF_Ca-bd_CS.
 IPR026219; Jagged/Serrate.
 IPR001007; VWF_C. 
Pfam
 PF01414; DSL
 PF00008; EGF
 PF07645; EGF_CA 
SMART
 SM00051; DSL
 SM00181; EGF
 SM00179; EGF_CA
 SM00214; VWC 
PROSITE
 PS00010; ASX_HYDROXYL
 PS51051; DSL
 PS00022; EGF_1
 PS01186; EGF_2
 PS50026; EGF_3
 PS01187; EGF_CA 
PRINTS
 PR02059; JAGGEDFAMILY.