Tag | Content |
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CPLM ID | CPLM-010402 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Tyrosine-protein phosphatase non-receptor type substrate 1 |
Protein Synonyms/Alias | SHP substrate 1; SHPS-1; Brain Ig-like molecule with tyrosine-based activation motifs; Bit; CD172 antigen-like family member A; Inhibitory receptor SHPS-1; Macrophage fusion receptor; MyD-1 antigen; Signal-regulatory protein alpha-1; Sirp-alpha-1; Signal-regulatory protein alpha-2; Sirp-alpha-2; Signal-regulatory protein alpha-3; Sirp-alpha-3; p84; CD172a |
Gene Name | SIRPA |
Gene Synonyms/Alias | BIT; MFR; MYD1; PTPNS1; SHPS1; SIRP |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
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183 | SPRDITLKWFKNGNE | ubiquitination | [1] |
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Reference | [1] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties. Chen Z, Zhou Y, Song J, Zhang Z. Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [ PMID: 23603789] |
Functional Description | Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function (By similarity). Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. |
Sequence Annotation | DOMAIN 32 137 Ig-like V-type. DOMAIN 148 247 Ig-like C1-type 1. DOMAIN 254 348 Ig-like C1-type 2. MOTIF 429 432 SH2-binding (Potential). MOTIF 439 444 SH3-binding (Potential). MOTIF 453 456 SH2-binding (Potential). MOTIF 470 473 SH2-binding (Potential). MOTIF 496 499 SH2-binding (Potential). MOD_RES 429 429 Phosphotyrosine; by Tyr-kinases MOD_RES 453 453 Phosphotyrosine; by Tyr-kinases MOD_RES 470 470 Phosphotyrosine; by Tyr-kinases (By MOD_RES 496 496 Phosphotyrosine; by Tyr-kinases (By CARBOHYD 245 245 N-linked (GlcNAc...). CARBOHYD 270 270 N-linked (GlcNAc...). CARBOHYD 292 292 N-linked (GlcNAc...). CARBOHYD 319 319 N-linked (GlcNAc...) (Potential). DISULFID 55 121 DISULFID 170 228 Potential. DISULFID 273 331 Potential. |
Keyword | 3D-structure; Alternative splicing; Complete proteome; Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane; Phosphoprotein; Polymorphism; Reference proteome; Repeat; SH3-binding; Signal; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 504 AA |
Protein Sequence | MEPAGPAPGR LGPLLCLLLA ASCAWSGVAG EEELQVIQPD KSVLVAAGET ATLRCTATSL 60 IPVGPIQWFR GAGPGRELIY NQKEGHFPRV TTVSDLTKRN NMDFSIRIGN ITPADAGTYY 120 CVKFRKGSPD DVEFKSGAGT ELSVRAKPSA PVVSGPAARA TPQHTVSFTC ESHGFSPRDI 180 TLKWFKNGNE LSDFQTNVDP VGESVSYSIH STAKVVLTRE DVHSQVICEV AHVTLQGDPL 240 RGTANLSETI RVPPTLEVTQ QPVRAENQVN VTCQVRKFYP QRLQLTWLEN GNVSRTETAS 300 TVTENKDGTY NWMSWLLVNV SAHRDDVKLT CQVEHDGQPA VSKSHDLKVS AHPKEQGSNT 360 AAENTGSNER NIYIVVGVVC TLLVALLMAA LYLVRIRQKK AQGSTSSTRL HEPEKNAREI 420 TQVQSLDTND ITYADLNLPK GKKPAPQAAE PNNHTEYASI QTSPQPASED TLTYADLDMV 480 HLNRTPKQPA PKPEPSFSEY ASVQVPRK 508 |
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