UniProt Accession

 RANG_MOUSE; P34022; P34023; Q3TL81; Q9D894; Q9DCA3 

Genbank Protein ID

 X56046; L25255; X56045; AK002989; AK008276; AK088781; AK151167; AK166642; AK167053; BC061140 

Genbank Nucleotide ID

 CAA39517.1; AAA16195.1; CAA39516.1; BAB22501.1; BAB25569.1; BAC40569.1; BAE30170.1; BAE38911.1; BAE39217.1; AAH61140.1 

Protein Name

 Ran-specific GTPase-activating protein 

Protein Synonyms/Alias

 HpaII tiny fragments locus 9a protein; Ran-binding protein 1; RANBP1 

Gene Name

 Ranbp1 

Gene Synonyms/Alias

 Htf9-a; Htf9a 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
50	EDEEELFKMRAKLFR	acetylation	[1]
50	EDEEELFKMRAKLFR	ubiquitination	[2]
68	ENDLPEWKERGTGDV	ubiquitination	[2]
150	LNAENAQKFKTKFEE	ubiquitination	[2]

Reference

 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Inhibits GTP exchange on Ran. Forms a Ran-GTP-RANBP1 trimeric complex. Increase GTP hydrolysis induced by the Ran GTPase activating protein RANGAP1. May act in an intracellular signaling pathway which may control the progression through the cell cycle by regulating the transport of protein and nucleic acids across the nuclear membrane. 

Sequence Annotation

 DOMAIN 26 164 RanBD1.
 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 13 13 Phosphothreonine (By similarity).
 MOD_RES 21 21 Phosphoserine (By similarity).
 MOD_RES 60 60 Phosphoserine.
 MOD_RES 150 150 N6-acetyllysine (By similarity).
 MOD_RES 182 182 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Complete proteome; GTPase activation; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 203 AA 

Protein Sequence

Gene Ontology

 GO:0005813; C:centrosome; IDA:MGI.
 GO:0005737; C:cytoplasm; IDA:MGI.
 GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
 GO:0046907; P:intracellular transport; IEA:InterPro.
 GO:0043547; P:positive regulation of GTPase activity; IEA:GOC.
 GO:0046604; P:positive regulation of mitotic centrosome separation; IDA:MGI.
 GO:0007051; P:spindle organization; IDA:MGI. 

Interpro

 IPR011993; PH_like_dom.
 IPR000156; Ran_bind_dom. 

Pfam

 PF00638; Ran_BP1 

SMART

 SM00160; RanBD 

PROSITE

 PS50196; RANBD1 

PRINTS