| Tag | Content |
|---|
| CPLM ID | CPLM-006919 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Essential nuclear protein 1 |
Protein Synonyms/Alias | |
Gene Name | ENP1 |
Gene Synonyms/Alias | MEG1; YBR247C; YBR1635 |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 85 | LAESERNKQFEARFT | ubiquitination | [1] | | 344 | IAGSVLAKVSVPALH | ubiquitination | [1] |
|
Reference | [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation. Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J. Nat Methods. 2013 Jul;10(7):676-82. [ PMID: 23749301] |
Functional Description | Required for normal export of the pre-40S particles from the nucleus to the cytoplasm. Its subcellular location and association with pre-40S subunit shifts from mixed cytoplasm/nucleus to all nuclear in RPS19 disruptions, suggesting it acts after the ribosomal protein. |
Sequence Annotation | MOD_RES 172 172 Phosphoserine; by ATM or ATR.
MOD_RES 190 190 Phosphoserine.
MOD_RES 404 404 Phosphoserine. |
Keyword | Complete proteome; Cytoplasm; Nucleus; Phosphoprotein; Reference proteome; Ribosome biogenesis. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 483 AA |
Protein Sequence | MARASSTKAR KQRHDPLLKD LDAAQGTLKK INKKKLAQND AANHDAANEE DGYIDSKASR 60
KILQLAKEQQ DEIEGEELAE SERNKQFEAR FTTMSYDDED EDEDEDEEAF GEDISDFEPE 120
GDYKEEEEIV EIDEEDAAMF EQYFKKSDDF NSLSGSYNLA DKIMASIREK ESQVEDMQDD 180
EPLANEQNTS RGNISSGLKS GEGVALPEKV IKAYTTVGSI LKTWTHGKLP KLFKVIPSLR 240
NWQDVIYVTN PEEWSPHVVY EATKLFVSNL TAKESQKFIN LILLERFRDN IETSEDHSLN 300
YHIYRAVKKS LYKPSAFFKG FLFPLVETGC NVREATIAGS VLAKVSVPAL HSSAALSYLL 360
RLPFSPPTTV FIKILLDKKY ALPYQTVDDC VYYFMRFRIL DDGSNGEDAT RVLPVIWHKA 420
FLTFAQRYKN DITQDQRDFL LETVRQRGHK DIGPEIRREL LAGASREFVD PQEANDDLMI 480
DVN 483 |
Gene Ontology | GO:0030686; C:90S preribosome; IDA:SGD. GO:0005737; C:cytoplasm; IDA:SGD. GO:0005730; C:nucleolus; IDA:SGD. GO:0030688; C:preribosome, small subunit precursor; IDA:SGD. GO:0030515; F:snoRNA binding; IDA:SGD. GO:0000447; P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IMP:SGD. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |