UniProt Accession

 NOP16_HUMAN; Q9Y3C1; B4DV13; D6RGD3; Q05D05; Q6IAI6; Q8IXL5 

Genbank Protein ID

 AY561704; AF151875; AF161460; AK300883; CR457169; AC138956; CH471195; BC019331; BC040106 

Genbank Nucleotide ID

 AAS66977.1; AAD34112.1; AAF29075.1; BAG62525.1; CAG33450.1; EAW85085.1; AAH19331.1; AAH40106.1 

Protein Name

 Nucleolar protein 16 

Protein Synonyms/Alias

 HBV pre-S2 trans-regulated protein 3 

Gene Name

 NOP16 

Gene Synonyms/Alias

 CGI-117; HSPC111 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
12	KGKTRRQKFGYSVNR	ubiquitination	[1]
90	RPKELVRKPYVLNDL	acetylation	[2]
106	AEASLPEKKGNTLSR	ubiquitination	[3]

Reference

 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

  

Sequence Annotation

 MOD_RES 8 8 Phosphothreonine.
 MOD_RES 16 16 Phosphoserine.
 MOD_RES 90 90 N6-acetyllysine.
 MOD_RES 144 144 Phosphothreonine.  

Keyword

 Acetylation; Alternative splicing; Complete proteome; Nucleus; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 178 AA 

Protein Sequence

Gene Ontology

 GO:0005730; C:nucleolus; IDA:HPA. 

Interpro

 IPR019002; Ribosome_biogenesis_Nop16. 

Pfam

 PF09420; Nop16 

SMART

  

PROSITE

  

PRINTS