UniProt Accession

 IRF2_HUMAN; P14316; D6RCK5; H0Y8S3; Q6IAS7; Q96B99 

Genbank Protein ID

 X15949; BT007264; AK312953; CR457077; AC099343; CH471056; CH471056; CH471056; BC015803 

Genbank Nucleotide ID

 CAA34073.1; AAP35928.1; BAG35793.1; CAG33358.1; EAX04677.1; EAX04678.1; EAX04680.1; AAH15803.1 

Protein Name

 Interferon regulatory factor 2 

Protein Synonyms/Alias

 IRF-2 

Gene Name

 IRF2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
29	PGLKWLNKEKKIFQI	acetylation	[1]
31	LKWLNKEKKIFQIPW	acetylation	[1]
32	KWLNKEKKIFQIPWM	acetylation	[1]
75	GVDKPDPKTWKANFR	acetylation	[1]
78	KPDPKTWKANFRCAM	acetylation	[1]
137	EDKVKHIKQEPVESS	sumoylation	[2]
166	AVLTSTIKNEVDSTV	sumoylation	[2]
293	PDLQVTIKEESNPVP	sumoylation	[2]

Reference

 [1] Interferon regulatory factor-2 regulates cell growth through its acetylation.
 Masumi A, Yamakawa Y, Fukazawa H, Ozato K, Komuro K.
 J Biol Chem. 2003 Jul 11;278(28):25401-7. [PMID: 12738767]
 [2] Regulation of IRF2 transcriptional activity by its sumoylation.
 Han KJ, Jiang L, Shu HB.
 Biochem Biophys Res Commun. 2008 Aug 8;372(4):772-8. [PMID: 18514056] 

Functional Description

 Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1 transcriptional activation. 

Sequence Annotation

 DNA_BIND 5 113 IRF tryptophan pentad repeat.
 MOD_RES 75 75 N6-acetyllysine.
 MOD_RES 78 78 N6-acetyllysine.
 CROSSLNK 137 137 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 166 166 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 293 293 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 Acetylation; Activator; Alternative splicing; Complete proteome; DNA-binding; Isopeptide bond; Nucleus; Reference proteome; Repressor; Transcription; Transcription regulation; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 349 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005925; C:focal adhesion; IDA:HPA.
 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0003677; F:DNA binding; IDA:UniProtKB.
 GO:0000975; F:regulatory region DNA binding; IEA:InterPro.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IMP:UniProtKB.
 GO:0007596; P:blood coagulation; TAS:Reactome.
 GO:0008283; P:cell proliferation; TAS:ProtInc.
 GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; TAS:ProtInc.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0060337; P:type I interferon-mediated signaling pathway; TAS:Reactome. 

Interpro

 IPR017431; Interferon_reg_fac-1/2.
 IPR019817; Interferon_reg_fac_CS.
 IPR001346; Interferon_reg_fact_DNA-bd_dom.
 IPR011991; WHTH_DNA-bd_dom. 

Pfam

 PF00605; IRF 

SMART

 SM00348; IRF 

PROSITE

 PS00601; IRF_1
 PS51507; IRF_2 

PRINTS

 PR00267; INTFRNREGFCT.