UniProt Accession

 TPM2_HUMAN; P07951; A6NM85; P06468; Q13894; Q53FM4; Q5TCU4; Q5TCU7; Q9UH67 

Genbank Protein ID

 M12126; M12125; X06825; M75165; M74817; AK223258; AL133410; AL133410; CH471071; BC011776; AF209746; J05247 

Genbank Nucleotide ID

 AAA61229.1; AAA36773.1; CAA29971.1; AAB59509.1; AAA61230.1; BAD96978.1; CAI10974.1; CAI10977.1; EAW58354.1; AAH11776.1; AAF17621.1; AAA51842.1 

Protein Name

 Tropomyosin beta chain 

Protein Synonyms/Alias

 Beta-tropomyosin; Tropomyosin-2 

Gene Name

 TPM2 

Gene Synonyms/Alias

 TMSB 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
30	EQAEADKKQAEDRCK	ubiquitination	[1]
37	KQAEDRCKQLEEEQQ	ubiquitination	[1]
48	EEQQALQKKLKGTED	ubiquitination	[1]
51	QALQKKLKGTEDEVE	ubiquitination	[1]
65	EKYSESVKEAQEKLE	ubiquitination	[1]
112	RLATALQKLEEAEKA	ubiquitination	[1]
118	QKLEEAEKAADESER	ubiquitination	[1]
128	DESERGMKVIENRAM	ubiquitination	[1]
152	EMQLKEAKHIAEDSD	ubiquitination	[1]
168	KYEEVARKLVILEGE	ubiquitination	[1]
205	RTMDQALKSLMASEE	ubiquitination	[1]
251	RSVAKLEKTIDDLEE	ubiquitination	[2]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization (By similarity). 

Sequence Annotation

 MOD_RES 1 1 N-acetylmethionine (By similarity).
 MOD_RES 61 61 Phosphoserine; by PIK3CG (By similarity).
 MOD_RES 252 252 Phosphothreonine (By similarity).
 MOD_RES 283 283 Phosphoserine (By similarity).  

Keyword

 Acetylation; Actin-binding; Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Disease mutation; Muscle protein; Nemaline myopathy; Phosphoprotein; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 284 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005862; C:muscle thin filament tropomyosin; TAS:ProtInc.
 GO:0003779; F:actin binding; IDA:UniProtKB.
 GO:0008307; F:structural constituent of muscle; TAS:ProtInc.
 GO:0030049; P:muscle filament sliding; TAS:Reactome.
 GO:0043462; P:regulation of ATPase activity; IDA:UniProtKB. 

Interpro

 IPR000533; Tropomyosin. 

Pfam

 PF00261; Tropomyosin 

SMART

  

PROSITE

 PS00326; TROPOMYOSIN 

PRINTS

 PR00194; TROPOMYOSIN.