CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-035000
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Ubiquitin carboxyl-terminal hydrolase 
Protein Synonyms/Alias
  
Gene Name
 LOC100911860 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
460DSKVQPIKEKDIMQQacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Hydrolase; Protease; Reference proteome; Thiol protease; Ubl conjugation pathway. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1235 AA 
Protein Sequence
MFGNLFEEDY SSVSSSQYGS GKKLKTKGLE PPAPREFTKL SGIRNQGGTC YLSSLLQTLH 60
FTPEFREALF SLGPEELGSL EDKDKPEAKV RIIPLQLQRL FAQLLLVDQE AASTTDLTDS 120
FGWTSDEEMR QHDVQELNRI LFSALETSLV GTSGHDLIHR LYHGTIVNQI VCKECKNVSE 180
RQEDFLDLTV AVKNVSGLED ALWNMYVEEE IFDYDNLYHC GTCDRLVKAA KSAKLRKLPP 240
FLTISLLRFN FDFVKCERYK DTSCYTFPLR INLKPFCEQS DMDDMEYMYD LFSVIIHKGG 300
CYGGHYHVYI KDVDHLGNWQ CQEEISDSAV NLKAPQNEEE TDDPLVVLKA ILLQEEANQI 360
PVDQLGQKLL IKTGISWNKK YRKQHGPLRK FLRLHPQVFL LSTDESTVSL QRSHFPQVPS 420
DPQSHEQIAH TLASEPPGLR DNISCPHWFD INDSKVQPIK EKDIMQQFQG KESAYMLFYR 480
KATLQRPSEA QANPRYRVPC HLLKEMDAAN VLLQTRRAEC DSANSTFELH LHLGPHYRFF 540
NGALHPAVSQ TESVWDLTFD KRKTVGDLRQ SIFQLLEFWE GDMVLSVAKR VPAGLHVYHT 600
LDGDELTLGE AEIADEEDIF VWNGVEVGGV QIQTGFDCEP LLLHILHLEL SGEGSECEQL 660
VESPHVFPAN AEVGTVFTAL GTPEGVLLMN SVESTDEECW TAIPQEDMKK TFREQGLRNG 720
SLILVQDSDS DDNSLLSKQG RWTSSMNELN WLQVKNFCQS GSEEKQVQIA VTMHTVVFDI 780
RIKAIKELKL MKELAENSCL RPIDRNGRLL CPVPDTSTLE EAEVKMGSSV GLCLGKAPTS 840
SQLFLFFALG TDIHPGAELE VIVEETLSVR DCLKIMLEKS GQQGEMWHLR KMDWCYEAGE 900
PLCEEDATLK ELMICSGDTL LLTEGKLPSP GHLKMPIWWY QPERLSGHRE SWDHLNCAFS 960
QGSSWGAAPT QGAPGPEPAE VSLLYLGDME ISEEATLAEL KSKALALPSV LKLAVQSTSL 1020
LRVWTVESKR PSRLLRTGWR QLKEYRLGRR TELCLELLQK EEDLGPRDVL LRTQLRIPGE 1080
RAYSLAKDLV WDTTRGWTAG SLRQRVADFY SLPVEKIEIA KYFPEKFEWL PISSWNQQIA 1140
KRKKKKNQDT LQGGPYYLKD GDTIGIKNLL FDDNDDFSTI RDDIGKENQK RTALEKKKSR 1200
EVQRTQSSDV FSNSGMPTRP RGPEASLSIH VASFR 1235 
Gene Ontology
 GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
 GO:0004221; F:ubiquitin thiolesterase activity; IEA:InterPro.
 GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro. 
Interpro
 IPR018200; Pept_C19ubi-hydrolase_C_CS.
 IPR001394; Peptidase_C19. 
Pfam
 PF00443; UCH 
SMART
  
PROSITE
 PS00972; UCH_2_1
 PS00973; UCH_2_2
 PS50235; UCH_2_3 
PRINTS