| Tag | Content |
|---|
| CPLM ID | CPLM-016802 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Deubiquitinating protein VCIP135 |
Protein Synonyms/Alias | Valosin-containing protein p97/p47 complex-interacting protein 1; Valosin-containing protein p97/p47 complex-interacting protein p135 |
Gene Name | Vcpip1 |
Gene Synonyms/Alias | Vcip135 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 181 | VNTVGYGKDRSGSLL | ubiquitination | [1] | | 330 | PGLIPAEKCTGRDGH | ubiquitination | [1] | | 361 | YIPLVGIKGAALPKL | ubiquitination | [1] | | 407 | GDRSLQDKYLLRLVA | ubiquitination | [1] | | 728 | EQASVMQKRKTEKLK | ubiquitination | [1] | | 1107 | VVEAQRKKLQEMVSS | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Acts as a deubiquitinating enzyme. Necessary for VCP- mediated reassembly of Golgi stacks after mitosis. May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER). Mediates dissociation of the ternary complex containing STX5A, NSFL1C and VCP (By similarity). |
Sequence Annotation | DOMAIN 207 360 OTU.
MOD_RES 407 407 N6-acetyllysine (By similarity).
MOD_RES 746 746 Phosphoserine (By similarity).
MOD_RES 762 762 Phosphothreonine (By similarity).
MOD_RES 993 993 Phosphoserine (By similarity).
MOD_RES 1196 1196 Phosphoserine (By similarity).
CROSSLNK 869 869 Glycyl lysine isopeptide (Lys-Gly) |
Keyword | Acetylation; Alternative splicing; Complete proteome; Endoplasmic reticulum; Golgi apparatus; Hydrolase; Isopeptide bond; Phosphoprotein; Protease; Reference proteome; Thiol protease; Ubl conjugation; Ubl conjugation pathway. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1220 AA |
Protein Sequence | MSQPPPPPPL PPPPPPPEAP QTSSSLAAAA SPGGLSKRRD RRILSGSCPD PKCQARLFFP 60
ASGSVSIECT ECGQRHEQQQ LLGVEEVTDP DVVLHNLLRN ALLGVTGAPK KNTELVKVMG 120
LSNYHCKLLS PILARYGMDK QTGRAKLLRD MNQGELFDCA LLGDRAFLIE PEHVNTVGYG 180
KDRSGSLLYL HDTLEDIKRA NKSQECLIPV HVDGDGHCLV HAVSRALVGR ELFWHALREN 240
LKQHFQQHLA RYQALFHDFI DAAEWEDIIN ECDPLFVPPE GVPLGLRNIH IFGLANVLHR 300
PIILLDSLSG MRSSGDYSAT FLPGLIPAEK CTGRDGHLNK PICIAWSSSG RNHYIPLVGI 360
KGAALPKLPM NLLPKAWGVP QDLIKKYIKL EEDGGCVIGG DRSLQDKYLL RLVAAMEEVF 420
MDKHGIHPSL VADVHQYFYR RTGVIGVQPE EVTAAAKKAV MDNRLHKCLL YGALSELHVP 480
SEWLAPGGKL YNLAKSTHGQ LRPDKNYSFP LNNLVCSYDP VKDVLLPDYG LSNLTACNWC 540
HGSSVRRVRG DGSIVYLDGD RTNSRSTGGK CGCGFKHFWE GKEYDNLPEA FPITLEWGGR 600
VVRETVYWFQ YESDPSLNSN VYDVAMKLVT KHFPGEFGSE ILVQKVVHTI LHQTAKKNPD 660
DYTPVNIDGA HAQRVGDVQG QELESQLPTK IILTGQKTKT LHKEELNMSK TERTIQQNIT 720
EQASVMQKRK TEKLKQEQKG QPRTVSPSTI RDGPSSAPAT PTKAPYSPTT SKEKKIRITT 780
NDGRQSMVTL KPSTTFFELQ ESIAREFNIP PYLQCIRYGF PPKELMPPQA GMEKEPVPLQ 840
HGDRITIEIL KGRAEGGPST AAHSAHTVKQ EEIAVTGKLS SKELQEQADK EMYSLCLLAT 900
LMGEDVWSYA KGLPHMFQQG GVFYNIMKKT MGMADGKHCT FPHLPGKTFV YNASEDRLEL 960
CVDAAGHFPI GPDVEDLVKE AVSQVRAEAT TRSRESSPSH GLLKLGSGGV VKKKSEQLHN 1020
VTAFQGKGHS LGTASSHPHI DPRARETLAV RKHNTGTDFS NSSIKTEPPV FTAASSNSEL 1080
IRIAPGVVTM RDGRQIDPDV VEAQRKKLQE MVSSIQASMD KHLRDQSAEQ APSDLSQRKV 1140
EVVSSVRPVN LQTGLPEPFS LTGGTENLNT ETTDSHVADV LGAAFATRSK AQKENSMEEP 1200
EEMDSQDAET TNTTEPMDHS 1220 |
Gene Ontology | GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell. GO:0005795; C:Golgi stack; IEA:UniProtKB-SubCell. GO:0004843; F:ubiquitin-specific protease activity; ISS:UniProtKB. GO:0016320; P:endoplasmic reticulum membrane fusion; IEA:Compara. GO:0090168; P:Golgi reassembly; IEA:Compara. GO:0007067; P:mitosis; IEA:Compara. GO:0016567; P:protein ubiquitination; ISS:UniProtKB. GO:0006508; P:proteolysis; IEA:UniProtKB-KW. |
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PROSITE | |
PRINTS | |