CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-033602
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Centrosomal protein of 192 kDa 
Protein Synonyms/Alias
  
Gene Name
 CEP192 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
59SIEKNKDKTDLPQSVubiquitination[1]
140YFIRSPEKREPIALIubiquitination[2]
212TLTADKGKTEDTFFMubiquitination[2]
222DTFFMSNKPQRYKDKubiquitination[1, 2, 3]
229KPQRYKDKLPDSGDSubiquitination[2]
297FLPNDLEKSNGSNALubiquitination[2]
308SNALDMEKYLKKTEVubiquitination[2]
340TWDLSLPKEQTTQDIubiquitination[2]
405NSAVVDVKTCSIDNKubiquitination[2]
421QDVGNDEKATSISTPubiquitination[2]
663KPDFRWSKDPSSKSGubiquitination[2]
697IRLALLGKSGLSCQVubiquitination[2]
1186QTMHFLAKVASSRKQubiquitination[2]
1311LGRTQLQKLALRNNSubiquitination[2]
1384MLARLEIKQLGNRSQubiquitination[2]
1415NLILEGVKKLSDSYMubiquitination[1]
1416LILEGVKKLSDSYMVubiquitination[2, 3]
1451GSRAAFVKAVGFKDSubiquitination[2]
1467KKVLLDPKVLRIFPDubiquitination[2]
1479FPDKFVLKERTQENVubiquitination[2]
1500SDRGINNKTATELSTubiquitination[1, 2, 3]
1528YRRALLHKPEMIKQIubiquitination[2]
1603EFLQPSSKASLESTSubiquitination[1, 2, 3]
1617SDLGASGKHGGNVSLubiquitination[1]
1842SLAPPYVKGVDESGDubiquitination[2]
1940IKIDHLVKPRRQAVSubiquitination[2]
2061LIGEALGKN******ubiquitination[2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2062 AA 
Protein Sequence
MDGCLDTETP TVSIQENVDV ASLKPISDSG INFTDAIWSP TCERRTCECH ESIEKNKDKT 60
DLPQSVVYQN EEGRWVTDLA YYTSFNSKQN LNVSLSDEMN EDFRSGSEAF DLIAQDEEEF 120
NKEHQFIQPS FGYFIRSPEK REPIALIRKS DVSRGNLEKE MAHLNHDLYS GDLNEQSQAQ 180
LSEGSITLQV EAVESTSQVD ENDVTLTADK GKTEDTFFMS NKPQRYKDKL PDSGDSMLRI 240
STIASAIAEA SVNTDPSQLA AMIKALSNKT RDKTFQEDEK QKDYSHVRHF LPNDLEKSNG 300
SNALDMEKYL KKTEVSRYES ALENFSRASM SDTWDLSLPK EQTTQDIHPV DLSATSVSVR 360
APEENTAAIV YVENGESENQ ESFRTINSSN SVTNRENNSA VVDVKTCSID NKLQDVGNDE 420
KATSISTPSD SYSSVRNPRI TSLCLLKDCE EIRDNRENQR QNECVSEISN SEKHVTFENH 480
RIVSPKNSDL KNTSPEHGGR GSEDEQESFR PSTSPLSHSS PSEISGTSSS GCALESFGSA 540
AQQQQPPCEQ ELSPLVCSPA GVSRLTYVSE PESSYPTTAT DDALEDRKSD ITSELSTTII 600
QGSPAALEER AMEKLREKVP FQNRGKGTLS SIIQNNSDTR KATETTSLSS KPEYVKPDFR 660
WSKDPSSKSG NLLETSEVGW TSNPEELDPI RLALLGKSGL SCQVGSATSH PVSCQEPIDE 720
DQRISPKDKS TAGREFSGQV SHQTTSENQC TPIPSSTVHS SVADMQNMPA AVHALLTQPS 780
LSAAPFAQRY LGTLPSTGST TLPQCHAGNA TVCGFSGGLP YPAVAGEPVQ NSVAVGICLG 840
SNIGSGWMGT SSLCNPYSNT LNQNLLSTTK PFPVPSVGTN CGIEPWDSGV TSGLGSVRVP 900
EELKLPHACC VGIASQTLLS VLNPTDRWLQ VSIGVLSISV NGEKVDLSTY RCLVFKNKAI 960
IRPHATEEIK VLFIPSSPGV FRCTFSVASW PCSTDAETIV QAEALASTVT LTAIAESPVI 1020
EVETEKKDVL DFGDLTYGGW KALPLKLINR THATVPIRLI INANAVAWRC FTFSKESVRA 1080
PVEVAPCADV VTRLAGPSVV NHMMPASYDG QDPEFLMIWV LFHSPKKQIS SSDILDSAEE 1140
FSAKVDIEVD SPNPTPVLRS VSLRARAGIA RIHAPRDLQT MHFLAKVASS RKQHLPLKNA 1200
GNIEVYLDIK VPEQGSHFSV DPKNLLLKPG EEHEVIVSFT PKDPEACEER ILKIFVQPFG 1260
PQYEVVLKGE VISSGSKPLS PGPCLDIPSI LSNKQFLAWG GVPLGRTQLQ KLALRNNSAS 1320
TTQHLRLLIR GQDQDCFQLQ NTFGSEQRLT SNCEIRIHPK EDIFISVLFA PTRLSCMLAR 1380
LEIKQLGNRS QPGIKFTIPL SGYGGTSNLI LEGVKKLSDS YMVTVNGLVP GKESKIVFSV 1440
RNTGSRAAFV KAVGFKDSQK KVLLDPKVLR IFPDKFVLKE RTQENVTLIY NPSDRGINNK 1500
TATELSTVYL FGGDEISRQQ YRRALLHKPE MIKQILPEHS VLQNINFVEA FQDELLVTEV 1560
YDLPQRPNDV QLFYGSMCKI ILSVIGEFRD CISSREFLQP SSKASLESTS DLGASGKHGG 1620
NVSLDVLPVK GPQGSPLLSR AARPPLDQLA SEEPWTVLPE HLILVAPSPC DMAKTGRFQI 1680
VNNSVRLLRF ELCWPAHCLT VTPQHGCVAP ESKLQILVSP NSSLSTKQSM FPWSGLIYIH 1740
CDDGQKKIVK VQIREDLTQV ELLTRLTSKP FGILSPVSEP SVSHLVKPMT KPPSTKVEIR 1800
NKSITFPTTE PGETSESCLE LENHGTTDVK WHLSSLAPPY VKGVDESGDV FRATYAAFRC 1860
SPISGLLESH GIQKVSITFL PRGRGDYAQF WDVECHPLKE PHMKHTLRFQ LSGQSIEAEN 1920
EPENACLSTD SLIKIDHLVK PRRQAVSEAS ARIPEQLDVT ARGVYAPEDV YRFRPTSVGE 1980
SRTLKVNLRN NSFITHSLKF LSPREPFYVK HSKYSLRAQH YINMPVQFKP KSAGKFEALL 2040
VIQTDEGKSI AIRLIGEALG KN 2062 
Gene Ontology
 GO:0005813; C:centrosome; IDA:HPA.
 GO:0005737; C:cytoplasm; IDA:HPA. 
Interpro
  
Pfam
  
SMART
  
PROSITE
  
PRINTS