UniProt Accession

 D3YTT7_MOUSE; D3YTT7 

Genbank Protein ID

 AC098849; CH466532 

Genbank Nucleotide ID

 EDL11947.1 

Protein Name

 40S ribosomal protein SA 

Protein Synonyms/Alias

 37 kDa laminin receptor precursor; 37/67 kDa laminin receptor; 67 kDa laminin receptor; Laminin receptor 1; Laminin-binding protein precursor p40 

Gene Name

 Rpsa-ps10 

Gene Synonyms/Alias

 Rpsa; mCG_2650 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
52	GIYIINLKRTWEKLL	acetylation	[1]
52	GIYIINLKRTWEKLL	ubiquitination	[2]
57	NLKRTWEKLLLAARA	acetylation	[1]
89	TGQRAVLKFAAATGA	acetylation	[1, 3, 4]
89	TGQRAVLKFAAATGA	succinylation	[3]
89	TGQRAVLKFAAATGA	ubiquitination	[2]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [4] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654] 

Functional Description

 Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a PPP1R16B-dependent substrate of PPP1CA (By similarity). 

Sequence Annotation

 REPEAT 230 232 -W-[ST] 1 (By similarity).
 REPEAT 247 249 -W-[ST] 2 (By similarity).
 REPEAT 266 268 -W-[ST] 3 (By similarity).
 REPEAT 275 277 -W-[ST] 4 (By similarity).
 REPEAT 293 295 -W-[ST] 5 (By similarity).
 REGION 54 113 Interaction with PPP1R16B (By
 REGION 161 180 Laminin-binding (By similarity).
 REGION 205 229 Laminin-binding (By similarity).
 REGION 242 295 Laminin-binding (By similarity).
 MOD_RES 2 2 N-acetylserine (By similarity).  

Keyword

 Acetylation; Cell membrane; Complete proteome; Cytoplasm; Membrane; Nucleus; Receptor; Reference proteome; Repeat; Ribonucleoprotein; Ribosomal protein. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 295 AA 

Protein Sequence

Gene Ontology

 GO:0022627; C:cytosolic small ribosomal subunit; IEA:HAMAP.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0005055; F:laminin receptor activity; IEA:HAMAP.
 GO:0003735; F:structural constituent of ribosome; IEA:HAMAP.
 GO:0007155; P:cell adhesion; IEA:HAMAP.
 GO:0000028; P:ribosomal small subunit assembly; IEA:HAMAP.
 GO:0006412; P:translation; IEA:HAMAP. 

Interpro

 IPR027504; 40S_ribosomal_SA.
 IPR001865; Ribosomal_S2.
 IPR018130; Ribosomal_S2_CS.
 IPR027498; Ribosomal_S2_euk.
 IPR005707; Ribosomal_S2_euk/arc.
 IPR023591; Ribosomal_S2_flav_dom. 

Pfam

 PF00318; Ribosomal_S2 

SMART

  

PROSITE

 PS00962; RIBOSOMAL_S2_1
 PS00963; RIBOSOMAL_S2_2 

PRINTS

 PR00395; RIBOSOMALS2.