CPLM-011915

CPLM 1.0 - Compendium of Protein Lysine Modification

Tag

Content

CPLM ID

CPLM-011915

UniProt Accession

KCNH2_HUMAN; Q12809; A5H1P7; D3DX04; O75418; O75680; Q9BT72; Q9BUT7; Q9H3P0

Genbank Protein ID

U04270; AB009071; AF363636; AJ512214; DQ784808; CH471173; AB044806; AJ010538; AJ010539; AJ010540; AJ010541; AJ010542; AJ010543; AJ010544; AJ010545; AJ010546; AJ010547; AJ010548; AJ010549; AJ010550; AJ010551; CH471173; BC001914; BC004311; AF052728

Genbank Nucleotide ID

AAA62473.1; BAA37096.1; AAL37559.1; CAD54447.1; ABQ01243.1; EAW54072.1; BAB19682.1; CAA09232.1; CAA09232.1; CAA09232.1; CAA09232.1; CAA09232.1; CAA09232.1; CAA09232.1; CAA09232.1; CAA09232.1; CAA09232.1; CAA09232.1; CAA09232.1; CAA09232.1; CAA09232.1; EAW54075.1; AAH01914.2; AAH04311.2; AAC69709.1

Protein Name

Potassium voltage-gated channel subfamily H member 2

Protein Synonyms/Alias

Eag homolog; Ether-a-go-go-related gene potassium channel 1; ERG-1; Eag-related protein 1; Ether-a-go-go-related protein 1; H-ERG; hERG-1; hERG1; Voltage-gated potassium channel subunit Kv11.1

Gene Name

KCNH2

Gene Synonyms/Alias

ERG; ERG1; HERG

Created Date

July 27, 2013

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Lysine Modification

Position	Peptide	Type	References
166	RAKTFRLKLPALLAL	ubiquitination	[1]
389	ADVLPEYKLQAPRIH	ubiquitination	[1]
741	RSLLQHCKPFRGATK	ubiquitination	[1]
757	CLRALAMKFKTTHAP	ubiquitination	[1]

Reference

[1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]

Functional Description

Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr). Isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1.

Sequence Annotation

DOMAIN 41 70 PAS.
DOMAIN 92 144 PAC.
NP_BIND 742 842 cNMP.
MOTIF 624 629 Selectivity filter (By similarity).
MOD_RES 320 320 Phosphoserine.
CARBOHYD 598 598 N-linked (GlcNAc...).

Keyword

3D-structure; Alternative splicing; Complete proteome; Deafness; Disease mutation; Glycoprotein; Ion channel; Ion transport; Long QT syndrome; Membrane; Phosphoprotein; Polymorphism; Potassium; Potassium channel; Potassium transport; Reference proteome; Short QT syndrome; Transmembrane; Transmembrane helix; Transport; Voltage-gated channel.

Sequence Source

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

Protein Length

1159 AA

Protein Sequence

MPVRRGHVAP QNTFLDTIIR KFEGQSRKFI IANARVENCA VIYCNDGFCE LCGYSRAEVM 60
QRPCTCDFLH GPRTQRRAAA QIAQALLGAE ERKVEIAFYR KDGSCFLCLV DVVPVKNEDG 120
AVIMFILNFE VVMEKDMVGS PAHDTNHRGP PTSWLAPGRA KTFRLKLPAL LALTARESSV 180
RSGGAGGAGA PGAVVVDVDL TPAAPSSESL ALDEVTAMDN HVAGLGPAEE RRALVGPGSP 240
PRSAPGQLPS PRAHSLNPDA SGSSCSLART RSRESCASVR RASSADDIEA MRAGVLPPPP 300
RHASTGAMHP LRSGLLNSTS DSDLVRYRTI SKIPQITLNF VDLKGDPFLA SPTSDREIIA 360
PKIKERTHNV TEKVTQVLSL GADVLPEYKL QAPRIHRWTI LHYSPFKAVW DWLILLLVIY 420
TAVFTPYSAA FLLKETEEGP PATECGYACQ PLAVVDLIVD IMFIVDILIN FRTTYVNANE 480
EVVSHPGRIA VHYFKGWFLI DMVAAIPFDL LIFGSGSEEL IGLLKTARLL RLVRVARKLD 540
RYSEYGAAVL FLLMCTFALI AHWLACIWYA IGNMEQPHMD SRIGWLHNLG DQIGKPYNSS 600
GLGGPSIKDK YVTALYFTFS SLTSVGFGNV SPNTNSEKIF SICVMLIGSL MYASIFGNVS 660
AIIQRLYSGT ARYHTQMLRV REFIRFHQIP NPLRQRLEEY FQHAWSYTNG IDMNAVLKGF 720
PECLQADICL HLNRSLLQHC KPFRGATKGC LRALAMKFKT THAPPGDTLV HAGDLLTALY 780
FISRGSIEIL RGDVVVAILG KNDIFGEPLN LYARPGKSNG DVRALTYCDL HKIHRDDLLE 840
VLDMYPEFSD HFWSSLEITF NLRDTNMIPG SPGSTELEGG FSRQRKRKLS FRRRTDKDTE 900
QPGEVSALGP GRAGAGPSSR GRPGGPWGES PSSGPSSPES SEDEGPGRSS SPLRLVPFSS 960
PRPPGEPPGG EPLMEDCEKS SDTCNPLSGA FSGVSNIFSF WGDSRGRQYQ ELPRCPAPTP 1020
SLLNIPLSSP GRRPRGDVES RLDALQRQLN RLETRLSADM ATVLQLLQRQ MTLVPPAYSA 1080
VTTPGPGPTS TSPLLPVSPL PTLTLDSLSQ VSQFMACEEL PPGAPELPQE GPTRRLSLPG 1140
QLGALTSQPL HRHGSDPGS 1159

Gene Ontology

GO:0005737; C:cytoplasm; IEA:Compara.
GO:0005635; C:nuclear envelope; IEA:Compara.
GO:0008076; C:voltage-gated potassium channel complex; TAS:ProtInc.
GO:0005251; F:delayed rectifier potassium channel activity; TAS:ProtInc.
GO:0005242; F:inward rectifier potassium channel activity; IEA:Compara.
GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
GO:0008015; P:blood circulation; NAS:ProtInc.
GO:0006936; P:muscle contraction; TAS:ProtInc.
GO:0086091; P:regulation of heart rate by cardiac conduction; IMP:MGI.
GO:0060307; P:regulation of ventricular cardiac muscle cell membrane repolarization; IEA:Compara.
GO:0023014; P:signal transduction by phosphorylation; IEA:GOC.
GO:0007268; P:synaptic transmission; TAS:Reactome.

Interpro

IPR018490; cNMP-bd-like.
IPR000595; cNMP-bd_dom.
IPR005821; Ion_trans_dom.
IPR003938; K_chnl_volt-dep_EAG/ELK/ERG.
IPR003967; K_chnl_volt-dep_ERG.
IPR001610; PAC.
IPR000014; PAS.
IPR000700; PAS-assoc_C.
IPR014710; RmlC-like_jellyroll.

Pfam

PF00027; cNMP_binding
PF00520; Ion_trans

SMART

SM00100; cNMP
SM00086; PAC
SM00091; PAS

PROSITE

PS00888; CNMP_BINDING_1
PS00889; CNMP_BINDING_2
PS50042; CNMP_BINDING_3
PS50113; PAC
PS50112; PAS

PRINTS

PR01463; EAGCHANLFMLY.
PR01470; ERGCHANNEL.