CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-012741
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Dual specificity protein phosphatase 7 
Protein Synonyms/Alias
 Dual specificity protein phosphatase PYST2 
Gene Name
 DUSP7 
Gene Synonyms/Alias
 PYST2 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
268TNLDVLGKYGIKYILubiquitination[1]
362NDAYDFVKRKKSNISubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Regulates the activity of the MAP kinase family in response to changes in the cellular environment. PYST2-S may act as a negative regulator of PYST2-L although it is unclear whether this is by competing for transcription, translation or activation factors. 
Sequence Annotation
 DOMAIN 68 187 Rhodanese.
 DOMAIN 308 376 Tyrosine-protein phosphatase.
 ACT_SITE 331 331 Phosphocysteine intermediate (By  
Keyword
 Alternative promoter usage; Complete proteome; Cytoplasm; Hydrolase; Polymorphism; Protein phosphatase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 419 AA 
Protein Sequence
MKNQLRGPPA RAHMSTSGAA AAGGTRAGSE PGAGSGSGAG TGAGAATGAG AMPCKSAEWL 60
QEELEARGGA SLLLLDCRPH ELFESSHIET AINLAIPGLM LRRLRKGNLP IRSIIPNHAD 120
KERFATRCKA ATVLLYDEAT AEWQPEPGAP ASVLGLLLQK LRDDGCQAYY LQGGFNKFQT 180
EYSEHCETNV DSSSSPSSSP PTSVLGLGGL RISSDCSDGE SDRELPSSAT ESDGSPVPSS 240
QPAFPVQILP YLYLGCAKDS TNLDVLGKYG IKYILNVTPN LPNAFEHGGE FTYKQIPISD 300
HWSQNLSQFF PEAISFIDEA RSKKCGVLVH CLAGISRSVT VTVAYLMQKM NLSLNDAYDF 360
VKRKKSNISP NFNFMGQLLD FERTLGLSSP CDNHASSEQL YFSTPTNHNL FPLNTLEST 419 
Gene Ontology
 GO:0005829; C:cytosol; IDA:UniProtKB.
 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0017017; F:MAP kinase tyrosine/serine/threonine phosphatase activity; IDA:UniProtKB.
 GO:0004725; F:protein tyrosine phosphatase activity; IEA:EC.
 GO:0045087; P:innate immune response; TAS:Reactome.
 GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; TAS:Reactome.
 GO:0048011; P:neurotrophin TRK receptor signaling pathway; TAS:Reactome.
 GO:0035335; P:peptidyl-tyrosine dephosphorylation; IDA:UniProtKB.
 GO:0051403; P:stress-activated MAPK cascade; TAS:Reactome.
 GO:0034166; P:toll-like receptor 10 signaling pathway; TAS:Reactome.
 GO:0034134; P:toll-like receptor 2 signaling pathway; TAS:Reactome.
 GO:0034138; P:toll-like receptor 3 signaling pathway; TAS:Reactome.
 GO:0034142; P:toll-like receptor 4 signaling pathway; TAS:Reactome.
 GO:0034146; P:toll-like receptor 5 signaling pathway; TAS:Reactome.
 GO:0034162; P:toll-like receptor 9 signaling pathway; TAS:Reactome.
 GO:0038123; P:toll-like receptor TLR1:TLR2 signaling pathway; TAS:Reactome.
 GO:0038124; P:toll-like receptor TLR6:TLR2 signaling pathway; TAS:Reactome.
 GO:0035666; P:TRIF-dependent toll-like receptor signaling pathway; TAS:Reactome. 
Interpro
 IPR000340; Dual-sp_phosphatase_cat-dom.
 IPR020422; Dual-sp_phosphatase_subgr_cat.
 IPR024950; DUSP.
 IPR008343; MKP.
 IPR001763; Rhodanese-like_dom.
 IPR000387; Tyr/Dual-sp_Pase. 
Pfam
 PF00782; DSPc
 PF00581; Rhodanese 
SMART
 SM00195; DSPc
 SM00450; RHOD 
PROSITE
 PS50206; RHODANESE_3
 PS00383; TYR_PHOSPHATASE_1
 PS50056; TYR_PHOSPHATASE_2
 PS50054; TYR_PHOSPHATASE_DUAL 
PRINTS
 PR01764; MAPKPHPHTASE.