UniProt Accession

 1433E_DROME; P92177; Q8IN86; Q8IN87; Q9VEA8 

Genbank Protein ID

 U84898; U84897; AE014297; AE014297; AE014297; AE014297 

Genbank Nucleotide ID

 AAC47520.1; AAC47519.1; AAF55519.2; AAN13764.1; AAN13765.1; AAN13766.1 

Protein Name

 14-3-3 protein epsilon 

Protein Synonyms/Alias

 Suppressor of Ras1 3-9 

Gene Name

 14-3-3epsilon 

Gene Synonyms/Alias

 14-3-3e; SR3-9; CG31196 

Created Date

 July 27, 2013 

Organism

 Drosophila melanogaster (Fruit fly) 

NCBI Taxa ID

 7227 

Lysine Modification

Position	Peptide	Type	References
69	IITSIEQKEENKGAE	acetylation	[1]
78	ENKGAEEKLEMIKTY	acetylation	[1]
83	EEKLEMIKTYRGQVE	acetylation	[1]
91	TYRGQVEKELRDICS	acetylation	[1]

Reference

 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 

Functional Description

 Positively regulates Ras-mediated pathways. Acts downstream or parallel to Raf, but upstream of nuclear factors in Ras signaling. Three mutants have been isolated, that suppress the rough eye phenotype caused by mutated Ras1 (sev-Ras1 v12). Inhibits yki activity by restricting its nuclear localization. 

Sequence Annotation

 MOD_RES 262 262 Phosphoserine.  

Keyword

 Alternative splicing; Complete proteome; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 262 AA 

Protein Sequence

Gene Ontology

 GO:0005694; C:chromosome; IDA:FlyBase.
 GO:0005737; C:cytoplasm; IDA:FlyBase.
 GO:0045172; C:germline ring canal; IDA:FlyBase.
 GO:0005875; C:microtubule associated complex; IDA:FlyBase.
 GO:0005634; C:nucleus; IDA:FlyBase.
 GO:0007411; P:axon guidance; IMP:FlyBase.
 GO:0008340; P:determination of adult lifespan; IMP:FlyBase.
 GO:0007294; P:germarium-derived oocyte fate determination; IMP:FlyBase.
 GO:0007095; P:mitotic G2 DNA damage checkpoint; IGI:FlyBase.
 GO:0008103; P:oocyte microtubule cytoskeleton polarization; IMP:FlyBase.
 GO:0007280; P:pole cell migration; IMP:FlyBase.
 GO:0045927; P:positive regulation of growth; IMP:FlyBase.
 GO:0007088; P:regulation of mitosis; IMP:FlyBase.
 GO:0009411; P:response to UV; IMP:FlyBase.
 GO:0048190; P:wing disc dorsal/ventral pattern formation; IGI:FlyBase. 

Interpro

 IPR000308; 14-3-3.
 IPR023409; 14-3-3_CS.
 IPR023410; 14-3-3_domain. 

Pfam

 PF00244; 14-3-3 

SMART

 SM00101; 14_3_3 

PROSITE

 PS00796; 1433_1
 PS00797; 1433_2 

PRINTS

 PR00305; 1433ZETA.