UniProt Accession

 ARL4A_HUMAN; P40617; A4D119; P80418; Q49AF5 

Genbank Protein ID

 U73960; AK313233; AF493890; CH236948; CH471073; BC001111; BC003027 

Genbank Nucleotide ID

 AAB39713.1; BAG36044.1; AAM12604.1; EAL24295.1; EAW93650.1; AAH01111.1; AAH03027.1 

Protein Name

 ADP-ribosylation factor-like protein 4A 

Protein Synonyms/Alias

  

Gene Name

 ARL4A 

Gene Synonyms/Alias

 ARL4 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
135	PVLIVANKQDLRNSL	ubiquitination	[1, 2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Recruits CYTH1, CYTH2, CYTH3 and CYTH4 to the plasma membrane in GDP-bound form. 

Sequence Annotation

 NP_BIND 27 34 GTP (By similarity).
 NP_BIND 75 79 GTP (By similarity).
 NP_BIND 134 137 GTP (By similarity).
 LIPID 2 2 N-myristoyl glycine (Potential).  

Keyword

 Cell membrane; Complete proteome; Cytoplasm; GTP-binding; Lipoprotein; Membrane; Myristate; Nucleotide-binding; Nucleus; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 200 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005730; C:nucleolus; IDA:UniProtKB.
 GO:0005886; C:plasma membrane; IDA:UniProtKB.
 GO:0005525; F:GTP binding; IDA:UniProtKB.
 GO:0050873; P:brown fat cell differentiation; IEA:Compara.
 GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. 

Interpro

 IPR027417; P-loop_NTPase.
 IPR005225; Small_GTP-bd_dom.
 IPR001806; Small_GTPase.
 IPR024156; Small_GTPase_ARF.
 IPR006689; Small_GTPase_ARF/SAR. 

Pfam

 PF00025; Arf 

SMART

 SM00177; ARF 

PROSITE

 PS51417; ARF 

PRINTS

 PR00449; RASTRNSFRMNG.