UniProt Accession

 UNG_ECOLI; P12295 

Genbank Protein ID

 J03725; D13169; D64044; U00096; AP009048 

Genbank Nucleotide ID

 AAA24743.1; BAA02448.1; BAA10923.1; AAC75633.1; BAA16466.1 

Protein Name

 Uracil-DNA glycosylase 

Protein Synonyms/Alias

 UDG 

Gene Name

 ung 

Gene Synonyms/Alias

 b2580; JW2564 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
15	HDVLAEEKQQPYFLN	acetylation	[1]
42	VTIYPPQKDVFNAFR	acetylation	[2]
147	GWETFTDKVISLINQ	acetylation	[2]
170	LWGSHAQKKGAIIDK	acetylation	[2]
177	KKGAIIDKQRHHVLK	acetylation	[2]
184	KQRHHVLKAPHPSPL	acetylation	[2]

Reference

 [1] Comprehensive profiling of protein lysine acetylation in Escherichia coli.
 Zhang K, Zheng S, Yang JS, Chen Y, Cheng Z.
 J Proteome Res. 2013 Feb 1;12(2):844-51. [PMID: 23294111]
 [2] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. 

Sequence Annotation

 ACT_SITE 64 64 Proton acceptor.  

Keyword

 3D-structure; Complete proteome; Cytoplasm; Direct protein sequencing; DNA damage; DNA repair; Glycosidase; Hydrolase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 229 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0004844; F:uracil DNA N-glycosylase activity; IEA:InterPro.
 GO:0006284; P:base-excision repair; IEA:InterPro. 

Interpro

 IPR018085; Ura-DNA_Glyclase_AS.
 IPR002043; Ura_DNA_glycsylse.
 IPR005122; Uracil-DNA_glycosylase-like. 

Pfam

 PF03167; UDG 

SMART

 SM00986; UDG 

PROSITE

 PS00130; U_DNA_GLYCOSYLASE 

PRINTS