CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039697
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 General vesicular transport factor p115 
Protein Synonyms/Alias
  
Gene Name
 USO1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
204RSNGAIQKIVAFENAacetylation[1]
204RSNGAIQKIVAFENAubiquitination[1, 2, 3, 4]
589GKENFIEKLGFISKHubiquitination[2]
635ELEGVITKAIYKSSEacetylation[5]
714KDQYNLLKIQLGKDNubiquitination[2]
800SEQVAELKQELATLKacetylation[5]
928LLADQDQKILSLKNKubiquitination[2]
Reference
 [1] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [5] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 971 AA 
Protein Sequence
MNFLRGVMGG QSAGPQHTEA ETVRGAAGLG LGKGSGQGRG RSTRRPEECG LKFRHSFRLV 60
KHILYHVTIN VSDSEIIGYA LDTLYNIISN EEEEEVGGSQ EENSTRQSED LGSQFTEIFI 120
KQQENVTLLL SLLEEFDFHV RWPGVKLLTS LLKQLGPQVQ QIILVSPMGV SRLMDLLADS 180
REVIRNDGVL LLQALTRSNG AIQKIVAFEN AFERLLDIIS EEGNSDGGIV VEDCLILLQN 240
LLKNNNSNQN FFKEGSYIQR MKPWFEVGDE NSGWSAQKVT NLHLMLQLVR VLVSPTNPPG 300
ATSSCQKAMF QCGLLQQLCT ILMATGVPAD ILTETINTVS EVIRGCQVNQ DYFASVNAPS 360
NPPRPAIVVL LMSMVNERQP FVLRCAVLYC FQCFLYKNQK GQGEIVSTLL PSTIDATGNS 420
VSAGQLLCGG LFSTDSLSNW CAAVALAHAL QENATQKEQL LRVQLATSIG NPPVSLLQQC 480
TNILSQGDKI DRRGSKIQTR VGLLMLLCTW LSNCPIAVTH FLHNSANVPF LTGQIAENLG 540
EEEQLVQGLC ALLLGISIYF NDNSLESYMK EKLKQLIEKR IGKENFIEKL GFISKHELYS 600
RASQKPQPNF PSPEYMIFDH EFTKLVKELE GVITKAIYKS SEEDKKEEEV KKTLEQHDNI 660
VTHYKNMIRE QDLQLEELRQ QVSTLKCQNE QLQTAVTQQV SQIQQHKDQY NLLKIQLGKD 720
NQHQGSYSEG AQMNGIQPEE IGRLREEIEE LKRNQELLQS QLTEKDSMIE NMKSSQTSGT 780
NEQSSAIVSA RDSEQVAELK QELATLKSQL NSQSVEITKL QTEKQELLQK TEAFAKSVEV 840
QGETETIIAT KTTDVEGRLS ALLQETKELK NEIKALSEER TAIKEQLDSS NSTIAILQTE 900
KDKLELEITD SKKEQDDLLV LLADQDQKIL SLKNKLKDLG HPVEEEDELE SGDQEDEDDE 960
SEDPGKDLDH I 971 
Gene Ontology
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0000139; C:Golgi membrane; IEA:InterPro.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:Compara.
 GO:0008565; F:protein transporter activity; IEA:Compara.
 GO:0006886; P:intracellular protein transport; IEA:Compara.
 GO:0045056; P:transcytosis; IEA:Compara.
 GO:0048280; P:vesicle fusion with Golgi apparatus; IEA:InterPro. 
Interpro
 IPR016024; ARM-type_fold.
 IPR006955; Uso1_p115_C.
 IPR024095; Vesicle_P115-like.
 IPR006953; Vesicle_Uso1_P115_head. 
Pfam
 PF04871; Uso1_p115_C
 PF04869; Uso1_p115_head 
SMART
  
PROSITE
  
PRINTS