CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018186
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Oxidoreductase NAD-binding domain-containing protein 1 
Protein Synonyms/Alias
  
Gene Name
 Oxnad1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
256AQISAELKPYVTDGRacetylation[1, 2]
Reference
 [1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [2] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654
Functional Description
  
Sequence Annotation
 DOMAIN 60 171 FAD-binding FR-type.
 NP_BIND 177 182 NAD (By similarity).  
Keyword
 Alternative splicing; Complete proteome; NAD; Oxidoreductase; Reference proteome; Signal. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 311 AA 
Protein Sequence
MAHVALIPGL SRGSVGAVCT QAASWGLKAS TLRHLTLASI IKSRRKTDHL ERTASVLRRE 60
VMAAAKVCEI THESPSVKSL RLLVADKDFS FKAGQWVDFF IPGVSVVGGF SICSSPQRLE 120
RDRIIELAVK YADHPPAVWV HNKCTLDSEV ALRVGGEFFF DPQPTDAPRN LILIAGGVGI 180
NPLLSILRHS ADLHRDHADK GRSYEIGTVK LFYSAKNTSE LLFKKDILDL VHEFPEKISC 240
SFHVTKQTAQ ISAELKPYVT DGRITEKEIR DHISAETLFY VCGPPPMTDF FSKHLESCHV 300
PKEHICFEKW W 311 
Gene Ontology
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW. 
Interpro
 IPR017927; Fd_Rdtase_FAD-bd.
 IPR001433; OxRdtase_FAD/NAD-bd.
 IPR001221; Phe_hydroxylase.
 IPR017938; Riboflavin_synthase-like_b-brl. 
Pfam
 PF00175; NAD_binding_1 
SMART
  
PROSITE
 PS51384; FAD_FR 
PRINTS
 PR00410; PHEHYDRXLASE.