UniProt Accession

 Q9JKY7_MOUSE; Q9JKY7 

Genbank Protein ID

 AC104325; AC113593; AF221525; CH466550 

Genbank Nucleotide ID

 AAF34652.1; EDL04505.1 

Protein Name

 Cytochrome P450 CYP2D22 

Protein Synonyms/Alias

 MCG20388, isoform CRA_b; Protein Cyp2d22 

Gene Name

 Cyp2d22 

Gene Synonyms/Alias

 mCG_20388 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
96	ALREALVKHSEDTAD	ubiquitination	[1]
150	HHFGLGKKSLEQWVT	ubiquitination	[1]
242	RIPGLVGKVFPGKRA	ubiquitination	[1]
262	DELLAEHKTTWDPTQ	ubiquitination	[1]
380	LPLGVPHKTSRDIEL	ubiquitination	[1]
407	TNLSSALKDETVWEK	ubiquitination	[1]
414	KDETVWEKPLCFHPE	acetylation	[2]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Heme; Iron; Metal-binding; Monooxygenase; Oxidoreductase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 500 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:MGI.
 GO:0043231; C:intracellular membrane-bounded organelle; IEA:Compara.
 GO:0008391; F:arachidonic acid monooxygenase activity; IEA:Compara.
 GO:0009055; F:electron carrier activity; IEA:InterPro.
 GO:0020037; F:heme binding; IEA:InterPro.
 GO:0005506; F:iron ion binding; IEA:InterPro.
 GO:0016712; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; IEA:InterPro.
 GO:0004509; F:steroid 21-monooxygenase activity; IEA:Compara.
 GO:0019369; P:arachidonic acid metabolic process; IEA:Compara.
 GO:0042416; P:dopamine biosynthetic process; IEA:Compara.
 GO:0017144; P:drug metabolic process; IEA:Compara.
 GO:0007565; P:female pregnancy; IEA:Compara.
 GO:0010033; P:response to organic substance; IEA:Compara. 

Interpro

 IPR001128; Cyt_P450.
 IPR017972; Cyt_P450_CS.
 IPR002401; Cyt_P450_E_grp-I.
 IPR008069; Cyt_P450_E_grp-I_CYP2D-like. 

Pfam

 PF00067; p450 

SMART

  

PROSITE

 PS00086; CYTOCHROME_P450 

PRINTS

 PR00463; EP450I.
 PR01686; EP450ICYP2D.
 PR00385; P450.