UniProt Accession

 HPRT_PANTR; A5A6I1 

Genbank Protein ID

 AB222109 

Genbank Nucleotide ID

 BAF62354.1 

Protein Name

 Hypoxanthine-guanine phosphoribosyltransferase 

Protein Synonyms/Alias

 HGPRT; HGPRTase 

Gene Name

 HPRT1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Pan troglodytes (Chimpanzee) 

NCBI Taxa ID

 9598 

Lysine Modification

Position	Peptide	Type	References
166	KVASLLVKRTPRSVG	ubiquitination	[1]
175	TPRSVGYKPDFVGFE	ubiquitination	[1]

Reference

 [1] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5- phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway (By similarity). 

Sequence Annotation

 NP_BIND 134 142 GMP (By similarity).
 NP_BIND 186 188 GMP (By similarity).
 ACT_SITE 138 138 Proton acceptor (By similarity).
 METAL 194 194 Magnesium (By similarity).
 BINDING 69 69 GMP (By similarity).
 BINDING 166 166 GMP (By similarity).
 BINDING 194 194 GMP; via carbonyl oxygen (By similarity).
 MOD_RES 2 2 N-acetylalanine (By similarity).  

Keyword

 Acetylation; Complete proteome; Cytoplasm; Glycosyltransferase; Magnesium; Metal-binding; Nucleotide-binding; Purine salvage; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 218 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IBA:RefGenome.
 GO:0052657; F:guanine phosphoribosyltransferase activity; ISS:UniProtKB.
 GO:0004422; F:hypoxanthine phosphoribosyltransferase activity; ISS:UniProtKB.
 GO:0000287; F:magnesium ion binding; IBA:RefGenome.
 GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
 GO:0006168; P:adenine salvage; IBA:RefGenome.
 GO:0046038; P:GMP catabolic process; ISS:UniProtKB.
 GO:0032263; P:GMP salvage; IBA:RefGenome.
 GO:0006178; P:guanine salvage; ISS:UniProtKB.
 GO:0043103; P:hypoxanthine salvage; ISS:UniProtKB.
 GO:0032264; P:IMP salvage; IBA:RefGenome.
 GO:0006166; P:purine ribonucleoside salvage; IBA:RefGenome. 

Interpro

 IPR005904; Hxn_phspho_trans.
 IPR000836; PRibTrfase_dom. 

Pfam

 PF00156; Pribosyltran 

SMART

  

PROSITE

 PS00103; PUR_PYR_PR_TRANSFER 

PRINTS