CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004779
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Glutamate receptor 2 
Protein Synonyms/Alias
 GluR-2; AMPA-selective glutamate receptor 2; GluR-B; GluR-K2; Glutamate receptor ionotropic, AMPA 2; GluA2 
Gene Name
 Gria2 
Gene Synonyms/Alias
 Glur2 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
850AKRMKVAKNPQNINPubiquitination[1]
882VYGIESVKI******ubiquitination[1]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
 Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. 
Sequence Annotation
 REGION 499 501 Glutamate binding.
 REGION 675 676 Glutamate binding.
 BINDING 471 471 Glutamate.
 BINDING 506 506 Glutamate.
 BINDING 726 726 Glutamate.
 MOD_RES 683 683 Phosphoserine; by PKC.
 MOD_RES 717 717 Phosphoserine; by PKG.
 MOD_RES 869 869 Phosphotyrosine (By similarity).
 MOD_RES 876 876 Phosphotyrosine.
 MOD_RES 880 880 Phosphoserine (By similarity).
 LIPID 610 610 S-palmitoyl cysteine (By similarity).
 LIPID 836 836 S-palmitoyl cysteine (By similarity).
 CARBOHYD 256 256 N-linked (GlcNAc...).
 CARBOHYD 370 370 N-linked (GlcNAc...).
 CARBOHYD 406 406 N-linked (GlcNAc...) (Potential).
 CARBOHYD 413 413 N-linked (GlcNAc...) (Potential).
 DISULFID 78 330
 DISULFID 739 794  
Keyword
 3D-structure; Alternative splicing; Cell junction; Cell membrane; Complete proteome; Disulfide bond; Endoplasmic reticulum; Glycoprotein; Ion channel; Ion transport; Ligand-gated ion channel; Lipoprotein; Membrane; Palmitate; Phosphoprotein; Postsynaptic cell membrane; Receptor; Reference proteome; RNA editing; Signal; Synapse; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 883 AA 
Protein Sequence
MQKIMHISVL LSPVLWGLIF GVSSNSIQIG GLFPRGADQE YSAFRVGMVQ FSTSEFRLTP 60
HIDNLEVANS FAVTNAFCSQ FSRGVYAIFG FYDKKSVNTI TSFCGTLHVS FITPSFPTDG 120
THPFVIQMRP DLKGALLSLI EYYQWDKFAY LYDSDRGLST LQAVLDSAAE KKWQVTAINV 180
GNINNDKKDE TYRSLFQDLE LKKERRVILD CERDKVNDIV DQVITIGKHV KGYHYIIANL 240
GFTDGDLLKI QFGGANVSGF QIVDYDDSLV SKFIERWSTL EEKEYPGAHT ATIKYTSALT 300
YDAVQVMTEA FRNLRKQRIE ISRRGNAGDC LANPAVPWGQ GVEIERALKQ VQVEGLSGNI 360
KFDQNGKRIN YTINIMELKT NGPRKIGYWS EVDKMVVTLT ELPSGNDTSG LENKTVVVTT 420
ILESPYVMMK KNHEMLEGNE RYEGYCVDLA AEIAKHCGFK YKLTIVGDGK YGARDADTKI 480
WNGMVGELVY GKADIAIAPL TITLVREEVI DFSKPFMSLG ISIMIKKPQK SKPGVFSFLD 540
PLAYEIWMCI VFAYIGVSVV LFLVSRFSPY EWHTEEFEDG RETQSSESTN EFGIFNSLWF 600
SLGAFMQQGC DISPRSLSGR IVGGVWWFFT LIIISSYTAN LAAFLTVERM VSPIESAEDL 660
SKQTEIAYGT LDSGSTKEFF RRSKIAVFDK MWTYMRSAEP SVFVRTTAEG VARVRKSKGK 720
YAYLLESTMN EYIEQRKPCD TMKVGGNLDS KGYGIATPKG SSLGNAVNLA VLKLNEQGLL 780
DKLKNKWWYD KGECGSGGGD SKEKTSALSL SNVAGVFYIL VGGLGLAMLV ALIEFCYKSR 840
AEAKRMKVAK NPQNINPSSS QNSQNFATYK EGYNVYGIES VKI 883 
Gene Ontology
 GO:0032281; C:alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex; IDA:UniProtKB.
 GO:0032279; C:asymmetric synapse; IDA:RGD.
 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0009986; C:cell surface; IDA:RGD.
 GO:0032839; C:dendrite cytoplasm; IDA:RGD.
 GO:0043198; C:dendritic shaft; IDA:UniProtKB.
 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0030426; C:growth cone; IDA:RGD.
 GO:0043204; C:perikaryon; IDA:RGD.
 GO:0014069; C:postsynaptic density; IDA:RGD.
 GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
 GO:0042734; C:presynaptic membrane; IDA:RGD.
 GO:0030672; C:synaptic vesicle membrane; IDA:RGD.
 GO:0043195; C:terminal bouton; IDA:RGD.
 GO:0004971; F:alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity; IDA:UniProtKB.
 GO:0005234; F:extracellular-glutamate-gated ion channel activity; IEA:InterPro.
 GO:0015277; F:kainate selective glutamate receptor activity; IDA:UniProtKB.
 GO:0030165; F:PDZ domain binding; IDA:UniProtKB.
 GO:0045184; P:establishment of protein localization; IMP:UniProtKB.
 GO:0050806; P:positive regulation of synaptic transmission; IMP:UniProtKB.
 GO:0051262; P:protein tetramerization; IDA:UniProtKB.
 GO:0031623; P:receptor internalization; IDA:UniProtKB.
 GO:0001919; P:regulation of receptor recycling; IMP:UniProtKB.
 GO:0051966; P:regulation of synaptic transmission, glutamatergic; IMP:UniProtKB.
 GO:0060992; P:response to fungicide; IEP:RGD.
 GO:0010226; P:response to lithium ion; IEP:UniProtKB.
 GO:0007268; P:synaptic transmission; IDA:RGD. 
Interpro
 IPR001828; ANF_lig-bd_rcpt.
 IPR019594; Glu_rcpt_Glu/Gly-bd.
 IPR001320; Iontro_glu_rcpt.
 IPR001508; NMDA_rcpt. 
Pfam
 PF01094; ANF_receptor
 PF00060; Lig_chan
 PF10613; Lig_chan-Glu_bd 
SMART
 SM00918; Lig_chan-Glu_bd
 SM00079; PBPe 
PROSITE
  
PRINTS
 PR00177; NMDARECEPTOR.