UniProt Accession

 RFC2_DROME; P53034; Q9VZH9 

Genbank Protein ID

 U15967; AE014296; AY094829 

Genbank Nucleotide ID

 AAB60241.1; AAF47843.1; AAM11182.1 

Protein Name

 Replication factor C subunit 2 

Protein Synonyms/Alias

 Activator 1 40 kDa subunit; A1 40 kDa subunit; Activator 1 subunit 2; Replication factor C 40 kDa subunit; RF-C 40 kDa subunit; RFC40; Replication factor C subunit 4; DmRfc4 

Gene Name

 RfC4 

Gene Synonyms/Alias

 RfC40; CG14999 

Created Date

 July 27, 2013 

Organism

 Drosophila melanogaster (Fruit fly) 

NCBI Taxa ID

 7227 

Lysine Modification

Position	Peptide	Type	References
172	CAMLRFTKLSDAQVL	acetylation	[1]

Reference

 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 

Functional Description

 The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. Subunit 2 binds ATP. 

Sequence Annotation

 NP_BIND 56 63 ATP (Potential).  

Keyword

 ATP-binding; Cell cycle; Complete proteome; DNA replication; DNA-binding; Nucleotide-binding; Nucleus; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 331 AA 

Protein Sequence

Gene Ontology

 GO:0005875; C:microtubule associated complex; IDA:FlyBase.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0003677; F:DNA binding; IMP:UniProtKB.
 GO:0017111; F:nucleoside-triphosphatase activity; IEA:InterPro.
 GO:0000077; P:DNA damage checkpoint; IMP:FlyBase.
 GO:0006281; P:DNA repair; TAS:FlyBase.
 GO:0000076; P:DNA replication checkpoint; IMP:FlyBase.
 GO:0006271; P:DNA strand elongation involved in DNA replication; TAS:FlyBase.
 GO:0016321; P:female meiosis chromosome segregation; IMP:FlyBase.
 GO:0046331; P:lateral inhibition; IMP:FlyBase.
 GO:0007076; P:mitotic chromosome condensation; IMP:FlyBase.
 GO:0022008; P:neurogenesis; IMP:FlyBase. 

Interpro

 IPR003593; AAA+_ATPase.
 IPR003959; ATPase_AAA_core.
 IPR008921; DNA_pol3_clamp-load_cplx_C.
 IPR027417; P-loop_NTPase.
 IPR013748; Rep_factorC_C_dom. 

Pfam

 PF00004; AAA
 PF08542; Rep_fac_C 

SMART

 SM00382; AAA 

PROSITE

  

PRINTS