| Tag | Content |
|---|
| CPLM ID | CPLM-007250 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Aldehyde dehydrogenase 5, mitochondrial |
Protein Synonyms/Alias | |
Gene Name | ALD5 |
Gene Synonyms/Alias | ALD3; ALDH5; YER073W |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 59 | FVASKQKKTFDVINP | acetylation | [1] | | 71 | INPSNEEKITTVYKA | acetylation | [1] | | 77 | EKITTVYKAMEDDVD | acetylation | [1] | | 108 | VEPEVRAKALFNLAD | acetylation | [1] | | 148 | GDVALVSKYLRSCGG | acetylation | [1] | | 169 | GNVIDTGKNHFTYSI | acetylation | [1] | | 276 | ATGRHIMKVAADTVK | acetylation | [1] | | 305 | FADADLDKAVKNIAF | acetylation | [1] | | 368 | QGAQTSDKQLHKILD | acetylation | [1] | | 381 | LDYVDVAKSEGARLV | acetylation | [1] | | 397 | GGARHGSKGYFVKPT | acetylation | [1] | | 402 | GSKGYFVKPTVFADV | acetylation | [1] | | 517 | SVRIAIDKPIR**** | acetylation | [1] |
|
Reference | [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae. Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C. Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [ PMID: 22865919] |
Functional Description | Minor mitochondrial aldehyde dehydrogenase isoform. Plays a role in regulation or biosynthesis of electron transport chain components. Involved in the biosynthesis of acetate during anaerobic growth on glucose. |
Sequence Annotation | NP_BIND 266 271 NAD (By similarity).
ACT_SITE 288 288 Proton acceptor (By similarity).
ACT_SITE 322 322 Nucleophile (By similarity). |
Keyword | Complete proteome; Mitochondrion; NAD; NADP; Oxidoreductase; Reference proteome; Transit peptide. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 520 AA |
Protein Sequence | MLSRTRAAAP NSRIFTRSLL RLYSQAPLRV PITLPNGFTY EQPTGLFING EFVASKQKKT 60
FDVINPSNEE KITTVYKAME DDVDEAVAAA KKAFETKWSI VEPEVRAKAL FNLADLVEKH 120
QETLAAIESM DNGKSLFCAR GDVALVSKYL RSCGGWADKI YGNVIDTGKN HFTYSIKEPL 180
GVCGQIIPWN FPLLMWSWKI GPALATGNTV VLKPAETTPL SALFASQLCQ EAGIPAGVVN 240
ILPGSGRVVG ERLSAHPDVK KIAFTGSTAT GRHIMKVAAD TVKKVTLELG GKSPNIVFAD 300
ADLDKAVKNI AFGIFYNSGE VCCAGSRIYI QDTVYEEVLQ KLKDYTESLK VGDPFDEEVF 360
QGAQTSDKQL HKILDYVDVA KSEGARLVTG GARHGSKGYF VKPTVFADVK EDMRIVKEEV 420
FGPIVTVSKF STVDEVIAMA NDSQYGLAAG IHTNDINKAV DVSKRVKAGT VWINTYNNFH 480
QNVPFGGFGQ SGIGREMGEA ALSNYTQTKS VRIAIDKPIR 520 |
Gene Ontology | GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell. GO:0005739; C:mitochondrion; IDA:SGD. GO:0004029; F:aldehyde dehydrogenase (NAD) activity; IEA:EC. GO:0033721; F:aldehyde dehydrogenase (NADP+) activity; IEA:EC. GO:0004030; F:aldehyde dehydrogenase [NAD(P)+] activity; IDA:SGD. GO:0019413; P:acetate biosynthetic process; IMP:SGD. GO:0006068; P:ethanol catabolic process; IEA:UniProtKB-UniPathway. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |