CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-036531
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 ATP citrate lyase, isoform F 
Protein Synonyms/Alias
  
Gene Name
 ATPCL 
Gene Synonyms/Alias
 CG8322; Dmel_CG8322 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
549EILIPVYKKMSDAIHacetylation[1]
963NKMRKEGKLILGIGHacetylation[1]
973LGIGHRVKSINNPDVacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 
Functional Description
  
Sequence Annotation
  
Keyword
 Acyltransferase; Complete proteome; Ligase; Lyase; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1095 AA 
Protein Sequence
MSAKAITEAS GKDILNRHLN THGAGAATCR FSTVNSTTDW SKLAVDHPWL LTTPLVCKPD 60
QLIKRRGKLG LIGVKKNFEQ VKQWIGERLN KDQKIGNAVG KLRNFIIEPF VPHTDAEEMY 120
VCIYSHRAAD TILFYHQGGV DIGDVDAKAV KLDVPVNSSL SLADVKSKLL KEVKDAGTKE 180
RIAKFVSALY TTYVDLYFTY LEINPLVVTA DNLYILDLAA KLDSTADFIC RPKWGEIDYP 240
PPFGRDAYPE EAYIADLDAK SGASLKLTIL NRNGRIWTMV AGGGASVIYS DTICDLGGAS 300
ELANYGEYSG APSEQQTYEY AKTILNLMTS SPKHPDGKVL ITGGGIANFT NVAATFQGII 360
TALREFQPKL VEHNVSIFVR RAGPNYQEGL RKMRDFGSTL GIPLHVFGPE THMTAICGMA 420
LGKRPIPQTA SVEFSTANFL LPGGQQAQAD LKAASDASEA LGSGSDEADS AGISGAQRNG 480
SSLNRKFFSN TTKAIVWGMQ QRAVQSMLDF DFICRRDEPS VVAMVYPFTG DHKQKYYWGH 540
KEILIPVYKK MSDAIHKHKE VDVMVNFASM RSAYESTLEV LEFPQIRTVA IIAEGIPENM 600
TRKLIIEADK KGVAIIGPAT VGGVKPGCFK IGNTGGMLDN ILHSKLYRPG SVAYVSRSGG 660
MSNELNNIIS KATDGVIEGI AIGGDRYPGS TFMDHILRYQ ADPETKLIVL LGEVGGTEEY 720
DVCAALKDGR ITKPLVAWCI GTCASMFTSE VQFGHAGSCA NSDRETATAK NKGLRDAGAY 780
VPDSFDTLGE LIHHVYGELV KTGRVVPKEE VPPPTVPMDY SWARELGLIR KPASFMTSIC 840
DERGQELIYA GMPISEVLSK DVGIGGVISL LWFQRCLPSY VCKFFEMCLM VTADHGPAVS 900
GAHNTIVCAR AGKDLVSSVV SGLLTIGDRF GGALDGSARQ FSEAYDTNLH PMEFVNKMRK 960
EGKLILGIGH RVKSINNPDV RVKIIKEFVL ENFPACPLLK YALEVEKITT NKKPNLILNV 1020
DGVIATAFVD MLRNSGSFTS EEAQEYINVG AINSLFVLGR SIGFIGHYMD QKRLKQGLYR 1080
HPWDDISYVI PEQYN 1095 
Gene Ontology
 GO:0005811; C:lipid particle; IDA:FlyBase.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0003878; F:ATP citrate synthase activity; ISS:FlyBase.
 GO:0048037; F:cofactor binding; IEA:InterPro.
 GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
 GO:0004775; F:succinate-CoA ligase (ADP-forming) activity; IEA:EC.
 GO:0044262; P:cellular carbohydrate metabolic process; IEA:InterPro. 
Interpro
 IPR014608; ATP-citrate_synthase.
 IPR013650; ATP-grasp_succ-CoA_synth-type.
 IPR013816; ATP_grasp_subdomain_2.
 IPR017440; Cit_synth/succinyl-CoA_lig_AS.
 IPR016142; Citrate_synth-like_lrg_a-sub.
 IPR016143; Citrate_synth-like_sm_a-sub.
 IPR002020; Citrate_synthase-like.
 IPR016141; Citrate_synthase-like_core.
 IPR003781; CoA-bd.
 IPR005810; CoA_lig_alpha.
 IPR005811; CoA_ligase.
 IPR016040; NAD(P)-bd_dom.
 IPR017866; Succ-CoA_synthase_bsu_CS.
 IPR016102; Succinyl-CoA_synth-like. 
Pfam
 PF08442; ATP-grasp_2
 PF00285; Citrate_synt
 PF02629; CoA_binding
 PF00549; Ligase_CoA 
SMART
 SM00881; CoA_binding 
PROSITE
 PS01216; SUCCINYL_COA_LIG_1
 PS00399; SUCCINYL_COA_LIG_2
 PS01217; SUCCINYL_COA_LIG_3 
PRINTS