CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014494
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Canalicular multispecific organic anion transporter 1 
Protein Synonyms/Alias
 ATP-binding cassette sub-family C member 2; Canalicular multidrug resistance protein; Multidrug resistance-associated protein 2 
Gene Name
 Abcc2 
Gene Synonyms/Alias
 Cmoat; Cmrp; Mrp2 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
798VGKHIFNKVVGPNGLacetylation[1]
949VEGQKLIKKEFVETGsumoylation[2]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Posttranslational regulation of Abcc2 expression by SUMOylation system.
 Minami S, Ito K, Honma M, Ikebuchi Y, Anzai N, Kanai Y, Nishida T, Tsukita S, Sekine S, Horie T, Suzuki H.
 Am J Physiol Gastrointest Liver Physiol. 2009 Feb;296(2):G406-13. [PMID: 19074644] 
Functional Description
 Mediates hepatobiliary excretion of numerous organic anions. 
Sequence Annotation
 DOMAIN 318 601 ABC transmembrane type-1 1.
 DOMAIN 633 857 ABC transporter 1.
 DOMAIN 975 1260 ABC transmembrane type-1 2.
 DOMAIN 1296 1530 ABC transporter 2.
 NP_BIND 667 674 ATP 1 (Potential).
 NP_BIND 1330 1337 ATP 2 (Potential).
 MOD_RES 281 281 Phosphoserine (By similarity).
 MOD_RES 874 874 Phosphoserine (By similarity).
 CARBOHYD 6 6 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1007 1007 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1010 1010 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1011 1011 N-linked (GlcNAc...) (Potential).  
Keyword
 ATP-binding; Complete proteome; Glycoprotein; Membrane; Nucleotide-binding; Phosphoprotein; Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1541 AA 
Protein Sequence
MDKFCNSTFW DLSLLESPEA DLPLCFEQTV LVWIPLGFLW LLAPWQLYSV YRSRTKRSSI 60
TKFYLAKQVF VVFLLILAAI DLSLALTEDT GQATVPPVRY TNPILYLCTW LLVLAVQHSR 120
QWCVRKNSWF LSLFWILSVL CGVFQFQTLI RALLKDSKSN MAYSYLFFVS YGFQIVLLIL 180
TAFSGPSDST QTPSVTASFL SSITFSWYDR TVLKGYKHPL TLEDVWDIDE GFKTRSVTSK 240
FEAAMTKDLQ KARQAFQRRL QKSQRKPEAT LHGLNKKQSQ SQDVLVLEEA KKKSEKTTKD 300
YPKSWLIKSL FKTFHVVILK SFILKLIHDL LVFLNPQLLK LLIGFVKSSN SYVWFGYICA 360
ILMFAVTLIQ SFCLQSYFQH CFVLGMCVRT TVMSSIYKKA LTLSNLARKQ YTIGETVNLM 420
SVDSQKLMDA TNYMQLVWSS VIQITLSIFF LWRELGPSIL AGVGVMVLLI PVNGVLATKI 480
RNIQVQNMKN KDKRLKIMNE ILSGIKILKY FAWEPSFQEQ VQGIRKKELK NLLRFGQLQS 540
LLIFILQITP ILVSVVTFSV YVLVDSANVL NAEKAFTSIT LFNILRFPLS MLPMVTSSIL 600
QASVSVDRLE RYLGGDDLDT SAIRRVSNFD KAVKFSEASF TWDPDLEATI QDVNLDIKPG 660
QLVAVVGTVG SGKSSLVSAM LGEMENVHGH ITIQGSTAYV PQQSWIQNGT IKDNILFGSE 720
YNEKKYQQVL KACALLPDLE ILPGGDMAEI GEKGINLSGG QKQRVSLARA AYQDADIYIL 780
DDPLSAVDAH VGKHIFNKVV GPNGLLAGKT RIFVTHGIHF LPQVDEIVVL GKGTILEKGS 840
YRDLLDKKGV FARNWKTFMK HSGPEGEATV NNDSEAEDDD DGLIPTMEEI PEDAASLAMR 900
RENSLRRTLS RSSRSSSRRG KSLKNSLKIK NVNVLKEKEK EVEGQKLIKK EFVETGKVKF 960
SIYLKYLQAV GWWSILFIIL FYGLNNVAFI GSNLWLSAWT SDSDNLNGTN NSSSHRDMRI 1020
GVFGALGLAQ GICLLISTLW SIYACRNASK ALHGQLLTNI LRAPMRFFDT TPTGRIVNRF 1080
SGDISTVDDL LPQTLRSWMM CFFGIAGTLV MICMATPVFA IIIIPLSILY ISVQVFYVAT 1140
SRQLRRLDSV TKSPIYSHFS ETVTGLPIIR AFEHQQRFLA WNEKQIDINQ KCVFSWITSN 1200
RWLAIRLELV GNLVVFCSAL LLVIYRKTLT GDVVGFVLSN ALNITQTLNW LVRMTSEAET 1260
NIVAVERISE YINVENEAPW VTDKRPPADW PRHGEIQFNN YQVRYRPELD LVLKGITCNI 1320
KSGEKVGVVG RTGAGKSSLT NCLFRILESA GGQIIIDGID VASIGLHDLR ERLTIIPQDP 1380
ILFSGSLRMN LDPFNKYSDE EVWRALELAH LRSFVSGLQL GLLSEVTEGG DNLSIGQRQL 1440
LCLGRAVLRK SKILVLDEAT AAVDLETDSL IQTTIRKEFS QCTVITIAHR LHTIMDSDKI 1500
MVLDNGKIVE YGSPEELLSN RGSFYLMAKE AGIENVNHTE L 1541 
Gene Ontology
 GO:0016324; C:apical plasma membrane; IDA:UniProtKB.
 GO:0005887; C:integral to plasma membrane; IEA:Compara.
 GO:0046581; C:intercellular canaliculus; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0042626; F:ATPase activity, coupled to transmembrane movement of substances; IEA:InterPro.
 GO:0008514; F:organic anion transmembrane transporter activity; TAS:RGD.
 GO:0006200; P:ATP catabolic process; IEA:GOC.
 GO:0030644; P:cellular chloride ion homeostasis; IDA:RGD.
 GO:0006855; P:drug transmembrane transport; IMP:RGD.
 GO:0015732; P:prostaglandin transport; IMP:RGD.
 GO:0046685; P:response to arsenic-containing substance; IEP:RGD.
 GO:0043627; P:response to estrogen stimulus; IDA:RGD.
 GO:0009408; P:response to heat; IEP:RGD.
 GO:0031427; P:response to methotrexate; IEP:RGD.
 GO:0006979; P:response to oxidative stress; IEP:RGD.
 GO:0070327; P:thyroid hormone transport; IMP:RGD. 
Interpro
 IPR003593; AAA+_ATPase.
 IPR003439; ABC_transporter-like.
 IPR017871; ABC_transporter_CS.
 IPR017940; ABC_transporter_type1.
 IPR001140; ABC_transptr_TM_dom.
 IPR011527; ABC_transptrTM_dom_typ1.
 IPR005292; Multidrug-R_assoc.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00664; ABC_membrane
 PF00005; ABC_tran 
SMART
 SM00382; AAA 
PROSITE
 PS50929; ABC_TM1F
 PS00211; ABC_TRANSPORTER_1
 PS50893; ABC_TRANSPORTER_2 
PRINTS