| Tag | Content |
|---|
| CPLM ID | CPLM-013427 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Serine/arginine repetitive matrix protein 1 |
Protein Synonyms/Alias | Plenty-of-prolines 101 |
Gene Name | Srrm1 |
Gene Synonyms/Alias | Pop101 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 470 | SEEDKGSKMAAADSV | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Part of pre- and post-splicing multiprotein mRNP complexes. Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates (By similarity). |
Sequence Annotation | DOMAIN 27 126 PWI.
REGION 1 156 Necessary for mRNA 3'-end cleavage and
REGION 1 151 Necessary for DNA and RNA-binding (By
REGION 298 707 Necessary for speckles and matrix
MOD_RES 1 1 N-acetylmethionine (By similarity).
MOD_RES 140 140 N6-acetyllysine (By similarity).
MOD_RES 207 207 Phosphoserine.
MOD_RES 209 209 Phosphoserine.
MOD_RES 211 211 Phosphoserine.
MOD_RES 220 220 Phosphoserine.
MOD_RES 227 227 Phosphoserine (By similarity).
MOD_RES 234 234 Phosphoserine (By similarity).
MOD_RES 260 260 Phosphoserine.
MOD_RES 387 387 Phosphoserine.
MOD_RES 389 389 Phosphoserine.
MOD_RES 391 391 Phosphoserine.
MOD_RES 400 400 Phosphoserine (By similarity).
MOD_RES 404 404 Phosphothreonine.
MOD_RES 412 412 Phosphoserine (By similarity).
MOD_RES 414 414 Phosphothreonine (By similarity).
MOD_RES 418 418 Phosphoserine (By similarity).
MOD_RES 427 427 Phosphoserine.
MOD_RES 429 429 Phosphoserine.
MOD_RES 434 434 Phosphoserine (By similarity).
MOD_RES 448 448 Phosphoserine.
MOD_RES 450 450 Phosphoserine (By similarity).
MOD_RES 461 461 Phosphoserine.
MOD_RES 463 463 Phosphoserine.
MOD_RES 476 476 Phosphoserine (By similarity).
MOD_RES 561 561 Phosphoserine.
MOD_RES 563 563 Phosphoserine.
MOD_RES 572 572 Phosphoserine.
MOD_RES 574 574 Phosphoserine.
MOD_RES 591 591 Phosphoserine.
MOD_RES 593 593 Phosphothreonine.
MOD_RES 600 600 Phosphothreonine.
MOD_RES 602 602 Phosphoserine.
MOD_RES 616 616 Phosphoserine.
MOD_RES 624 624 Phosphoserine.
MOD_RES 626 626 Phosphoserine.
MOD_RES 633 633 Phosphothreonine.
MOD_RES 635 635 Phosphoserine.
MOD_RES 645 645 Phosphoserine.
MOD_RES 647 647 Phosphoserine.
MOD_RES 655 655 Phosphoserine.
MOD_RES 657 657 Phosphoserine.
MOD_RES 672 672 Phosphoserine.
MOD_RES 694 694 Phosphoserine.
MOD_RES 702 702 Phosphoserine.
MOD_RES 704 704 Phosphoserine.
MOD_RES 714 714 Phosphoserine.
MOD_RES 723 723 Phosphoserine.
MOD_RES 725 725 Phosphoserine.
MOD_RES 731 731 Phosphoserine.
MOD_RES 733 733 Phosphoserine.
MOD_RES 766 766 Phosphoserine.
MOD_RES 779 779 Phosphoserine.
MOD_RES 781 781 Phosphoserine.
MOD_RES 784 784 Phosphoserine.
MOD_RES 789 789 Phosphoserine (By similarity).
MOD_RES 793 793 Phosphoserine.
MOD_RES 795 795 Phosphoserine.
MOD_RES 797 797 Phosphoserine.
MOD_RES 810 810 Phosphoserine.
MOD_RES 814 814 Phosphoserine.
MOD_RES 816 816 Phosphoserine.
MOD_RES 818 818 Phosphoserine (By similarity).
MOD_RES 822 822 Phosphoserine.
MOD_RES 832 832 Phosphoserine.
MOD_RES 834 834 Phosphothreonine (By similarity).
MOD_RES 836 836 Phosphoserine (By similarity).
MOD_RES 913 913 Phosphothreonine.
MOD_RES 915 915 Phosphoserine. |
Keyword | Acetylation; Alternative splicing; Complete proteome; DNA-binding; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein; Reference proteome; RNA-binding; Spliceosome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 946 AA |
Protein Sequence | MDAGFFRGTS AEQDNRFSNK QKKLLKQLKF AECLEKKVDM SKVNLEVIKP WITKRVTEIL 60
GFEDDVVIEF IFNQLEVKNP DSKMMQINLT GFLNGKNARE FMGELWPLLL SAQENIAGIP 120
SAFLELKKEE IKQRQIEQEK LASLKKQDED KDKRDKEEKE SSREKRERSR SPRRRKSRSP 180
SPRRRSSPVR RERKRSHSRS PRHRTKSRSP SPAPEKKEKS PELPEPSVRM KDSSVQEATS 240
TSDILKAPKP EPVPEPKEPS PEKNSKKEKE KTRPRSRSRS KSRSRTRSRS PSHTRPRRRH 300
RSRSRSYSPR RRPSPRRRPS PRRRTPPRRM PPPPRHRRSR SPGRRRRRSS ASLSGSSSSS 360
SSSRSRSPPK KPPKRTSSPP RKTRRLSPSA SPPRRRHRPS SPATPPPKTR HSPTPQQSNR 420
TRKSRVSVSP GRTSGKVTKH KGTEKRESPS PAPKPRKVEL SESEEDKGSK MAAADSVQQR 480
RQYRRQNQQS SSDSGSSSTS EDERPKRSHV KNGEVGRRRR HSPSRSASPS PRKRQKETSP 540
RMQMGKRWQS PVTKSSRRRR SPSPPPARRR RSPSPAPPPP PPPPPPRRRR SPTPPPRRRT 600
PSPPPRRRSP SPRRYSPPIQ RRYSPSPPPK RRTASPPPPP KRRASPSPPP KRRVSHSPPP 660
KQRSPTVTKR RSPSLSSKHR KGSSPGRSTR EARSPQPNKR HSPSPRPRAP QTSSPPPVRR 720
GASASPQGRQ SPSPSTRPIR RVSRTPEPKK IKKTAMATQR NIRRVSKSPK ADSLSRAASP 780
SPQSVRRVSS SRSVSGSPEP AAKKPPAPPS PVQSQSPSTN WSPAVPAKKA KSPTPSLSPA 840
RNSDQEGGGK KKKKKKDKKH KKDKKHKKHK KHKKEKAVTI ATPATAAPAA VSAATTTSAQ 900
EEPAAAPEPR KETESEAEDD NLDDLERHLR EKALRSMRKA QVSPQS 946 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |