| Tag | Content |
|---|
| CPLM ID | CPLM-013337 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | ATPase family AAA domain-containing protein 5 |
Protein Synonyms/Alias | Chromosome fragility-associated gene 1 protein |
Gene Name | Atad5 |
Gene Synonyms/Alias | Frag1 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 75 | KTSLTTEKPQSTKAY | acetylation | [1] |
|
Reference | [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways. Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y. Mol Cell. 2013 Jun 27;50(6):919-30. [ PMID: 23806337] |
Functional Description | Involved in DNA damage response. Involved in a RAD9A- related damage checkpoint, a pathway that is important in determining whether DNA damage is compatible with cell survival or whether it requires cell elimination by apoptosis. Modulates the RAD9A interaction with BCL2 and thereby induces DNA damages- induced apoptosis. |
Sequence Annotation | NP_BIND 1119 1126 ATP (Potential).
MOTIF 1415 1419 LXCXE motif.
MOD_RES 44 44 Phosphoserine (By similarity).
MOD_RES 215 215 Phosphoserine (By similarity).
MOD_RES 353 353 Phosphoserine (By similarity).
MOD_RES 366 366 Phosphoserine (By similarity).
MOD_RES 603 603 Phosphoserine (By similarity).
MOD_RES 1104 1104 Phosphoserine (By similarity). |
Keyword | Alternative splicing; ATP-binding; Complete proteome; DNA damage; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1826 AA |
Protein Sequence | MVGVLSMAAA AAPLPVKDYE IEPCKKRRKD DDNSSCETIT KYLSPIGKTG DKVFSPPKPS 60
NILHYFRKTS LTTEKPQSTK AYKIKPSPPL LVGNSKDCKT PLEVFSNREF KRKRKRVSLS 120
SQLNDIKIQD ECPVEISNND SKEDGGLSDC VESSASVSLY KEHVEVLAES IEDSRNQPNT 180
KSSKKKVNPK QCTTKSDDRI LRKRKRSKVT GQSESVPLAD ELSLPEDGGK DSKLTKPSLA 240
EENDSRTHAT KRADLKESTI TVSYEEFVKS HKAAKVEEIP DPAVPACVPS GPGEAVKSGS 300
EGELSGSCEP SPQLHLKTVT VLAQVHPTPP KKKGKIPPIF LKQKQPELEN SLSDPENEQP 360
VQKRKSNVVI QEGQLELAVL EAWNSEASVP KCSMEERQQF MRAFRQPPPD TLKNGFKKPL 420
EKQKDPSEKS VHEGDSSSEK IIENPNIQRV SSQGCLQSHA DRGSFPKEKS KKPNKKGKKT 480
RTTAGGNREE NIQKEKTAFS LKDEQDQNSL RRSVRQKSEV LKSNALLNSE NLVCEDTAHD 540
SVQMSLCNRN KSRSSSTPTR DMVTHHRAEP GSSLEYVSTR QPIRRSLRSC STPATNALGG 600
TESEDAQDTI PVKASTPKSA RTSEKHNLYT AELIIVSSDS ESPIRMKFTR ISTPKKSKKS 660
SKKSETTEEE LTSQKKKANS TSKNISKAKE LIEEAKAFQI GGSKTEETVV PLRRSSRHQA 720
RSAKEKSPEI DDSVIVIDSS PTSIREPEKS QKKLQNLNDV LGKKLNKSSK NVPGKMKIAP 780
LFLAKRTKRA AIPVFDLDES SQDSSEQTQD CDVQFKAKRD FLMSGLPDLL KRQIAKKAAA 840
LDVYNAVSTS FQRVVHVQQK DDEYWLWHLK PPSCPLLTEF KELNTKVTDL SEYVVAFGEF 900
STLNPNPRSN PAAVMMRTRK DFTKEVRNLL LEEIKCSNPE FSLEKYFPLL LKKRIEHQVL 960
CEGHGKQASP QLQPDVSQKE TKRKQVATGN QKSKRKRQNE YSVSPEEMKG RSKDLDERIS 1020
SSCTNLDPSR DSGTEDMLWT EKYQPQNSNE LIGNELAVKK LHSWLKDWKR RAELEERHNL 1080
KGKRDEKEEG ILDLSDSTDF KGSSDDEENR LCNTVLITGP TGVGKTAAVY ACAQELGFKI 1140
FEVNASSQRS GRQILSQLKE ATQSHQVDKQ GVNSQKPCFF NNYNIGKSPK KLNSPGKVVT 1200
SPRKLPPSSP KTSGQKRALL PKTLANYFKV SSKSKSNDDV GALMGDDKGV KNSSLEQRQL 1260
IQTKSTNANN SHIKDVGAEE SNRKKATSLI LFEEVDVIFD EDAGFLNAVK TFMATTKRPV 1320
ILTTSDPTFS LVFDGCFEEI NFSIPSLLNV ASYLQVICLV ENFRTDFKDF VTLLTANACD 1380
IRKSILYLQF WIRSGGGILE ERPLSHCREN SRNTLVCSED GSDANINSKK PKRNRVALPR 1440
CDTGCAEALF GLKNIASPSQ DLLSLLKHKI TTKEEWQKLI QVLTEFHVQN IDLLHSNLEV 1500
ILPLPVHVVP DVRGAYGFPV TTQASAPASM GHLTRKQSKD QPLRKSQKRK QKKMVILDDS 1560
DLFDTGLDFS GELPSLSPAP SLSVEDNIRR DSNPEIKTQN SGFKPHSVPQ PPKTLAEKKC 1620
CMLVSHCLNS LSEFMENMSF IDALLTDPGE QNELGRSAFH WTNGRVKSGL CDEFSLENRD 1680
RWAPQSAGEL KATAEALSFT ECSSTISKAL ESLNSCKQLE RDPTNELTVC VSQRRHDACF 1740
RQSAANLDNA DKRMAVIKSV FSSRSFLTLG NKQASIIDYL PTLRNICRTE KLKEQEKNKR 1800
RFLHYFEGIH LEIPEETITT LAADFP 1826 |
Gene Ontology | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0017111; F:nucleoside-triphosphatase activity; IEA:InterPro. GO:0006974; P:response to DNA damage stimulus; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |