UniProt Accession

 HXA7_HUMAN; P31268; A4D191; O43368; O43486; O95655; Q9NSC8; Q9UDM1 

Genbank Protein ID

 AF026397; AJ005814; AF032095; X84803; X84804; CH236948; AC004080; CH471073; U92543 

Genbank Nucleotide ID

 AAB94604.1; CAA06713.1; AAD01939.2; CAA59270.1; CAA59270.1; EAL24221.1; EAW93877.1; AAD00727.1 

Protein Name

 Homeobox protein Hox-A7 

Protein Synonyms/Alias

 Homeobox protein Hox 1.1; Homeobox protein Hox-1A 

Gene Name

 HOXA7 

Gene Synonyms/Alias

 HOX1A 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
103	LAKGACDKTDEGALH	ubiquitination	[1, 2]
147	YQTLELEKEFHFNRY	ubiquitination	[3]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 

Functional Description

 Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. 

Sequence Annotation

 DNA_BIND 130 189 Homeobox.
 MOTIF 119 124 Antp-type hexapeptide.  

Keyword

 Complete proteome; Developmental protein; DNA-binding; Homeobox; Nucleus; Polymorphism; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 230 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IC:UniProtKB.
 GO:0043565; F:sequence-specific DNA binding; IDA:UniProtKB.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:Compara.
 GO:0001525; P:angiogenesis; IEP:UniProtKB.
 GO:0009952; P:anterior/posterior pattern specification; IEA:Compara.
 GO:0048704; P:embryonic skeletal system morphogenesis; IEA:Compara.
 GO:0001953; P:negative regulation of cell-matrix adhesion; IDA:UniProtKB.
 GO:0045617; P:negative regulation of keratinocyte differentiation; IDA:MGI.
 GO:0002686; P:negative regulation of leukocyte migration; IDA:UniProtKB.
 GO:0045656; P:negative regulation of monocyte differentiation; IDA:UniProtKB.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0048863; P:stem cell differentiation; IEA:Compara.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR017995; Homeobox_antennapedia.
 IPR001827; Homeobox_Antennapedia_CS.
 IPR017970; Homeobox_CS.
 IPR020479; Homeobox_metazoa.
 IPR001356; Homeodomain.
 IPR009057; Homeodomain-like. 

Pfam

 PF00046; Homeobox 

SMART

 SM00389; HOX 

PROSITE

 PS00032; ANTENNAPEDIA
 PS00027; HOMEOBOX_1
 PS50071; HOMEOBOX_2 

PRINTS

 PR00025; ANTENNAPEDIA.
 PR00024; HOMEOBOX.