CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-025683
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Postreplication repair protein hRAD18p variant 
Protein Synonyms/Alias
  
Gene Name
  
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
83RILDELVKSLNFARNubiquitination[1]
110SPASSSSKNLAVKVYubiquitination[1]
115SSKNLAVKVYTPVASubiquitination[1]
151STSELLIKENKSKFSubiquitination[1]
161KSKFSPQKEASPAAKubiquitination[1]
186APDPSEAKRPEPPSTubiquitination[1]
197PPSTSTLKQVTKVDCubiquitination[1]
245HKRKPLPKTVYNLLSubiquitination[1]
309QEIENIEKTRMRLEAubiquitination[1, 2]
318RMRLEASKLNESVMVubiquitination[1]
328ESVMVFTKDQTEKEIubiquitination[1]
341EIDEIHSKYRKKHKSubiquitination[1]
Reference
 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
 Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
 J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572] 
Functional Description
  
Sequence Annotation
  
Keyword
 Metal-binding; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 495 AA 
Protein Sequence
MDSLAESRWP PGLAVMKTID DLLRCGICFE YFNIAMIIPQ CSHNYCSLCI RKFLSYKTQC 60
PTCCVTVTEP DLKNNRILDE LVKSLNFARN HLLQFALESP ARSPASSSSK NLAVKVYTPV 120
ASRQSLKQGS RLMDNFLIRE MSGSTSELLI KENKSKFSPQ KEASPAAKTK ETRSVEEIAP 180
DPSEAKRPEP PSTSTLKQVT KVDCPVCGVN IPESHINKHL DSCLSREEKK ESLRSSVHKR 240
KPLPKTVYNL LSDRDLKKKL KEHGLSIQGN KQQLIKRHQE FVHMYNAQRD ALHPKSAAEI 300
VQEIENIEKT RMRLEASKLN ESVMVFTKDQ TEKEIDEIHS KYRKKHKSEF QLLVDQARKG 360
YKKIAGMSQK TVTITKEDES TEKLSSVCMG QEDNMTSVTN HFSQSKLDSP EELEPDREED 420
SSSCIDIQEV LSSSESDSCN SSSSDIIRDL LEEEEAWEAS HKNDLQDTEI SPRQNRRTRA 480
AESAEIEPRN KRNRN 495 
Gene Ontology
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006281; P:DNA repair; IEA:InterPro. 
Interpro
 IPR003034; SAP_dom.
 IPR006642; Znf_Rad18_put.
 IPR001841; Znf_RING.
 IPR013083; Znf_RING/FYVE/PHD.
 IPR017907; Znf_RING_CS. 
Pfam
 PF02037; SAP 
SMART
 SM00184; RING
 SM00513; SAP
 SM00734; ZnF_Rad18 
PROSITE
 PS50800; SAP
 PS00518; ZF_RING_1
 PS50089; ZF_RING_2 
PRINTS