UniProt Accession

 H10_HUMAN; P07305; B2R6I0; B4DRD6; Q6FG88; Q8N6R3 

Genbank Protein ID

 X03473; CR456502; CR542220; AK299209; AK312583; Z97630; CH471095; BC000145; BC029046 

Genbank Nucleotide ID

 CAA27190.1; CAG30388.1; CAG47016.1; BAG61248.1; BAG35477.1; CAB42829.1; EAW60188.1; AAH00145.1; AAH29046.1 

Protein Name

 Histone H1.0 

Protein Synonyms/Alias

 Histone H1'; Histone H1(0); Histone H1.0, N-terminally processed 

Gene Name

 H1F0 

Gene Synonyms/Alias

 H1FV 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
27	KKSTDHPKYSDMIVA	ubiquitination	[1, 2]
40	VAAIQAEKNRAGSSR	ubiquitination	[1, 2, 3]
52	SSRQSIQKYIKSHYK	acetylation	[4]
52	SSRQSIQKYIKSHYK	ubiquitination	[1]
59	KYIKSHYKVGENADS	acetylation	[4]
59	KYIKSHYKVGENADS	ubiquitination	[1, 2, 3]
82	LVTTGVLKQTKGVGA	ubiquitination	[1, 2]
85	TGVLKQTKGVGASGS	ubiquitination	[1]
164	AKKPKTVKAKPVKAS	acetylation	[5]

Reference

 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [5] Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome.
 Morselli E, Mariño G, Bennetzen MV, Eisenberg T, Megalou E, Schroeder S, Cabrera S, Bénit P, Rustin P, Criollo A, Kepp O, Galluzzi L, Shen S, Malik SA, Maiuri MC, Horio Y, López-Otín C, Andersen JS, Tavernarakis N, Madeo F, Kroemer G.
 J Cell Biol. 2011 Feb 21;192(4):615-29. [PMID: 21339330] 

Functional Description

 Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. The H1F0 histones are found in cells that are in terminal stages of differentiation or that have low rates of cell division. 

Sequence Annotation

 DOMAIN 24 97 H15.
 MOD_RES 1 1 N-acetylmethionine.
 MOD_RES 2 2 N-acetylthreonine; partial; in Histone
 MOD_RES 4 4 Deamidated asparagine; partial.  

Keyword

 Acetylation; Alternative splicing; Chromosome; Complete proteome; Direct protein sequencing; DNA-binding; Nucleus; Phosphoprotein; Reference proteome; RNA editing. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 194 AA 

Protein Sequence

Gene Ontology

 GO:0005794; C:Golgi apparatus; IDA:HPA.
 GO:0000790; C:nuclear chromatin; IDA:UniProtKB.
 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0000786; C:nucleosome; IEA:InterPro.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0006309; P:apoptotic DNA fragmentation; TAS:Reactome.
 GO:0006334; P:nucleosome assembly; IEA:InterPro. 

Interpro

 IPR005818; Histone_H1/H5.
 IPR005819; Histone_H5.
 IPR011991; WHTH_DNA-bd_dom. 

Pfam

 PF00538; Linker_histone 

SMART

 SM00526; H15 

PROSITE

 PS51504; H15 

PRINTS

 PR00624; HISTONEH5.