CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-027750
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Insulin receptor substrate 2 insertion mutant 
Protein Synonyms/Alias
  
Gene Name
 IRS2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
297LEAMKALKELFEFRPubiquitination[1]
Reference
 [1] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789
Functional Description
  
Sequence Annotation
  
Keyword
 Receptor. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1339 AA 
Protein Sequence
MASPPRHGPP GPASGDGPNL NNNNNNNNNN HSVRKCGYLR KQKHGHKRFF VLRGPGAGGD 60
EATAGGGSAP QPPRLEYYES EKKWRSKAGA PKRVIALDCC LNINKRADAK HKYLIALYTK 120
DEYFAVAAEN EQEQEGWYRA LTDLVSEGRA AAGDAPPAAA PAASCSASLP GALGGSAGAA 180
GAEDSYGLVA PATAAYREVW QVNLKPKGLG QSKNLTGVYR LCLSARTIGF VKLNCEQPSV 240
TLQLMNIRRC GHSDSFFFIE VGRSAVTGPG ELWMQADDSV VAQNIHETIL EAMKALKELF 300
EFRPRSKSQS SGSSATHPIS VPGARRHHHL VNLPPSQTGL VRRSRTDSLA ATPPAAKCSS 360
CRVRTASEGD GGAAAGAAAA GARPVSVAGS PLSPGPVRAP LSRSHTLSGG CGGRGSKVAL 420
LPAGGALQHS RSMSMPVAHS PPAATSPGSL SSSSGHGSGS YPPPPGPHPP LPHPLHHGPG 480
QRPSSGSASA SGSPSDPGFM SLDEYGSSPG DLRAFCSHRS NTPESIAETP PARDGGGGGE 540
FYGYMTMDRP LSHCGRSYRR VSGDAAQDLD RGLRKRTYSL TTPARQRPVP QPSSASLDEY 600
TLMRATFSGS AGRLCPSCPA SSPKVAYHPY PEDYGDIEIG SHRSSSSNLG ADDGYMPMTP 660
GAALAGSGSG SCRSDDYMPM SPASVSAPKQ ILQPRAAAAA AAAVPSAGPA GPAPTSAAGR 720
TFPASGGGYK ASSPAESSPE DSGYMRMWCG SKLSMEHADG KLLPNGDYLN VSPSDAVTTG 780
TPPDFFSAAL HPGGEPLRGV PGCCYSSLPR SYKAPYTCGG DSDQYVLMSS PVGRILEEER 840
LEPQATPGPS QAASAFGAGP TQPPHPVVPS PVRPSGGRPE GFLGQRGRAV RPTRLSLEGL 900
PSLPSMHEYP LPPEPKSPGE YINIDFGEPG ARLSPPAPPL LASAASSSSL LSASSPASSL 960
GSGTPGTSSD SRQRSPLSDY MNLDFSSPKS PKPGAPSGHP VGSLDGLLSP EASSPYPPLP 1020
PRPSASPSSS LQPPPPPPAP GELYRLPPAS AVATAQGPGA ASSLSSDTGD NGDYTEMAFG 1080
VAATPPQPIA APPKPEAARV ASPTSGVKRL SLMEQVSGVE AFLQASQPPD PHRGAKVIRA 1140
DPQGGRRRHS SETFSSTTTV TPVSPSFAHN PKRHNSASVE NVSLRKSSEG GVGVGPGGGD 1200
EPPTSPRQLQ PAPPLAPQGR PWTPGQPGGL VGCPGSGGSP MRRETSAGFQ NGLNYIAIDV 1260
REEPGLPPQP QPPPPPLPQP GDKSSWGRTR SLGGLISAVG VGSTGGGCGG PGPGALPPAN 1320
TYASIDFLSH HLKEATIVK 1339 
Gene Ontology
 GO:0005543; F:phospholipid binding; IEA:InterPro. 
Interpro
 IPR002404; Insln_rcpt_S1.
 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology. 
Pfam
 PF02174; IRS
 PF00169; PH 
SMART
 SM00233; PH
 SM00310; PTBI 
PROSITE
 PS51064; IRS_PTB
 PS50003; PH_DOMAIN 
PRINTS
 PR00628; INSULINRSI.