UniProt Accession

 H4_ARATH; P59259; P02308 

Genbank Protein ID

 M17132; M17133; AC007583; AC007583; AC005727; AC007184; AL162459; AL133298; AL132960; AB006705; AB015475; CP002684; CP002684; CP002684; CP002685; CP002686; CP002686; CP002686; CP002688; CP002688; AF325058; AF334729; AY057609; AY062717; AY063857; AY093353; AY099675; AY124836; AY128855; AY142651; AY085175; AY085495; AY085965; AY086789; AY086185; AY087061; AY087188 

Genbank Nucleotide ID

 AAA32810.1; AAA32811.1; AAF75089.1; AAF75072.1; AAC79580.1; AAM15445.1; CAB82817.1; CAB62023.1; CAB88335.1; BAB09507.1; BAB08365.1; AEE28158.1; AEE28187.1; AEE28188.1; AEC08165.1; AEE78091.1; AEE78146.1; AEE79133.1; AED97220.1; AED97260.1; AAG40410.1; AAG50107.1; AAL14404.1; AAL32795.1; AAL36213.1; AAM13352.1; AAM20526.1; AAM70545.1; AAM91255.1; AAN13189.1; AAM61726.1; AAM62721.1; AAM63175.1; AAM63839.1; AAM64264.1; AAM64622.1; AAM64744.1 

Protein Name

 Histone H4 

Protein Synonyms/Alias

  

Gene Name

 At1g07660; F24B9.25; At1g07820; F24B9.8; At2g28740; F8N16.2, T11P11.4; At3g45930; F16L2_140; At3g46320; F18L15.40; At3g53730; F5K20_30; At5g59690; MTH12.10; At5g59970; MMN10.22 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Arabidopsis thaliana (Mouse-ear cress) 

NCBI Taxa ID

 3702 

Lysine Modification

Position	Peptide	Type	References
6	**MSGRGKGGKGLGK	acetylation	[1, 2, 3]
9	SGRGKGGKGLGKGGA	acetylation	[1, 2, 3]
13	KGGKGLGKGGAKRHR	acetylation	[2, 3, 4, 5, 6]
17	GLGKGGAKRHRKVLR	acetylation	[1, 2, 3]
21	GGAKRHRKVLRDNIQ	acetylation	[2]

Reference

 [1] In vitro specificities of Arabidopsis co-activator histone acetyltransferases: implications for histone hyperacetylation in gene activation.
 Earley KW, Shook MS, Brower-Toland B, Hicks L, Pikaard CS.
 Plant J. 2007 Nov;52(4):615-26. [PMID: 17877703]
 [2] Distinctive core histone post-translational modification patterns in Arabidopsis thaliana.
 Zhang K, Sridhar VV, Zhu J, Kapoor A, Zhu JK.
 PLoS One. 2007 Nov 21;2(11):e1210. [PMID: 18030344]
 [3] Lysine acetylation is a widespread protein modification for diverse proteins in Arabidopsis.
 Wu X, Oh MH, Schwarz EM, Larue CT, Sivaguru M, Imai BS, Yau PM, Ort DR, Huber SC.
 Plant Physiol. 2011 Apr;155(4):1769-78. [PMID: 21311030]
 [4] Genetic control of developmental changes induced by disruption of Arabidopsis histone deacetylase 1 (AtHD1) expression.
 Tian L, Wang J, Fong MP, Chen M, Cao H, Gelvin SB, Chen ZJ.
 Genetics. 2003 Sep;165(1):399-409. [PMID: 14504245]
 [5] Arabidopsis GCN5, HD1, and TAF1/HAF2 interact to regulate histone acetylation required for light-responsive gene expression.
 Benhamed M, Bertrand C, Servet C, Zhou DX.
 Plant Cell. 2006 Nov;18(11):2893-903. [PMID: 17085686]
 [6] HBO1 histone acetylase activity is essential for DNA replication licensing and inhibited by Geminin.
 Miotto B, Struhl K.
 Mol Cell. 2010 Jan 15;37(1):57-66. [PMID: 20129055] 

Functional Description

 Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. 

Sequence Annotation

 DNA_BIND 17 21
 MOD_RES 2 2 N-acetylserine (By similarity).
 MOD_RES 6 6 N6-acetyllysine (By similarity).
 MOD_RES 9 9 N6-acetyllysine (By similarity).
 MOD_RES 13 13 N6-acetyllysine (By similarity).
 MOD_RES 17 17 N6-acetyllysine (By similarity).
 MOD_RES 21 21 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Alternative splicing; Chromosome; Complete proteome; DNA-binding; Nucleosome core; Nucleus; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 103 AA 

Protein Sequence

Gene Ontology

 GO:0009507; C:chloroplast; IDA:TAIR.
 GO:0005829; C:cytosol; IDA:TAIR.
 GO:0005730; C:nucleolus; IDA:TAIR.
 GO:0000786; C:nucleosome; NAS:TAIR.
 GO:0005886; C:plasma membrane; IDA:TAIR.
 GO:0009506; C:plasmodesma; IDA:TAIR.
 GO:0009579; C:thylakoid; IDA:TAIR.
 GO:0005774; C:vacuolar membrane; IDA:TAIR.
 GO:0003677; F:DNA binding; ISS:TAIR.
 GO:0006334; P:nucleosome assembly; IEA:InterPro.
 GO:0009414; P:response to water deprivation; IEP:TAIR. 

Interpro

 IPR009072; Histone-fold.
 IPR007125; Histone_core_D.
 IPR001951; Histone_H4.
 IPR019809; Histone_H4_CS. 

Pfam

 PF00125; Histone 

SMART

 SM00417; H4 

PROSITE

 PS00047; HISTONE_H4 

PRINTS

 PR00623; HISTONEH4.