CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015720
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 26S proteasome non-ATPase regulatory subunit 11 
Protein Synonyms/Alias
 26S proteasome regulatory complex subunit p42B; 26S proteasome regulatory subunit Rpn6 
Gene Name
 Rpn6 
Gene Synonyms/Alias
 CG10149 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
417VVDTLYQKAKKLS**acetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 
Functional Description
 Component of the lid subcomplex of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. In the complex, RPN6 is required for proteasome assembly (By similarity). May act as linker between 19S regulatory subunit and the 20S proteasome core. 
Sequence Annotation
 DOMAIN 286 387 PCI.
 MOD_RES 24 24 Phosphoserine.  
Keyword
 3D-structure; Alternative splicing; Complete proteome; Phosphoprotein; Proteasome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 422 AA 
Protein Sequence
MAGATLFERA QALSSVNREE QDSSLLNKLV RDQEGAENDE ERIRIKEQGI LQQGELYKQE 60
GKAKELADLI KVTRPFLSSI SKAKAAKLVR SLVDMFLDMD AGTGIEVQLC KDCIEWAKQE 120
KRTFLRQSLE ARLIALYFDT ALYTEALALG AQLLRELKKL DDKNLLVEVQ LLESKTYHAL 180
SNLPKARAAL TSARTTANAI YCPPKVQGAL DLQSGILHAA DERDFKTAFS YFYEAFEGFD 240
SVDSVKALTS LKYMLLCKIM LGQSDDVNQL VSGKLAITYS GRDIDAMKSV AEASHKRSLA 300
DFQAALKEYK KELAEDVIVQ AHLGTLYDTM LEQNLCRIIE PYSRVQVAHV AESIQLPMPQ 360
VEKKLSQMIL DKKFSGILDQ GEGVLIVFEE TPVDKTYERV LETIQSMGKV VDTLYQKAKK 420
LS 422 
Gene Ontology
 GO:0005875; C:microtubule associated complex; IDA:FlyBase.
 GO:0008541; C:proteasome regulatory particle, lid subcomplex; ISS:FlyBase.
 GO:0043161; P:proteasomal ubiquitin-dependent protein catabolic process; IC:FlyBase. 
Interpro
 IPR013143; PAM.
 IPR000717; PCI_dom.
 IPR011990; TPR-like_helical.
 IPR011991; WHTH_DNA-bd_dom. 
Pfam
 PF01399; PCI 
SMART
 SM00753; PAM
 SM00088; PINT 
PROSITE
  
PRINTS