CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005934
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Catenin delta-1 
Protein Synonyms/Alias
 Cadherin-associated Src substrate; CAS; p120 catenin; p120(ctn); p120(cas) 
Gene Name
 Ctnnd1 
Gene Synonyms/Alias
 Catns; Kiaa0384 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
878PLIDRNQKSDNNYSTubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Binds to and inhibits the transcriptional repressor ZBTB33, which may lead to activation of target genes of the Wnt signaling pathway (By similarity). Associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. Promotes GLIS2 C-terminal cleavage. 
Sequence Annotation
 REPEAT 358 395 ARM 1.
 REPEAT 398 437 ARM 2.
 REPEAT 441 475 ARM 3.
 REPEAT 476 516 ARM 4.
 REPEAT 534 573 ARM 5.
 REPEAT 583 624 ARM 6.
 REPEAT 653 693 ARM 7.
 REPEAT 700 739 ARM 8.
 REPEAT 740 780 ARM 9.
 REPEAT 781 826 ARM 10.
 MOTIF 622 635 Nuclear localization signal.
 MOD_RES 1 1 N-acetylmethionine (By similarity).
 MOD_RES 4 4 Phosphoserine (By similarity).
 MOD_RES 47 47 Phosphoserine (By similarity).
 MOD_RES 112 112 Phosphotyrosine; by FYN (By similarity).
 MOD_RES 228 228 Phosphotyrosine.
 MOD_RES 230 230 Phosphoserine.
 MOD_RES 252 252 Phosphoserine.
 MOD_RES 257 257 Phosphotyrosine.
 MOD_RES 268 268 Phosphoserine (By similarity).
 MOD_RES 269 269 Phosphoserine.
 MOD_RES 288 288 Phosphoserine; by PAK7/PAK5 (By
 MOD_RES 291 291 Phosphotyrosine.
 MOD_RES 320 320 Phosphoserine.
 MOD_RES 346 346 Phosphoserine.
 MOD_RES 349 349 Phosphoserine.
 MOD_RES 352 352 Phosphoserine.
 MOD_RES 811 811 Phosphoserine (By similarity).
 MOD_RES 847 847 Phosphoserine (By similarity).
 MOD_RES 857 857 Phosphoserine.
 MOD_RES 859 859 Phosphoserine.
 MOD_RES 864 864 Phosphoserine.
 MOD_RES 865 865 Phosphotyrosine.
 MOD_RES 879 879 Phosphoserine (By similarity).
 MOD_RES 904 904 Phosphotyrosine.
 MOD_RES 916 916 Phosphothreonine (By similarity).
 MOD_RES 920 920 Phosphoserine.  
Keyword
 Acetylation; Alternative splicing; Cell adhesion; Cell membrane; Coiled coil; Complete proteome; Cytoplasm; Membrane; Nucleus; Phosphoprotein; Reference proteome; Repeat; Transcription; Transcription regulation; Wnt signaling pathway. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 938 AA 
Protein Sequence
MDDSEVESTA SILASVKEQE AQFEKLTRAL EEERRHVSAQ LERVRVSPQD ANSLMANGTL 60
TRRHQNGRFV GDADLERQKF SDLKLNGPQD HNHLLYSTIP RMQEPGQIVE TYTEEDPEGA 120
MSVVSVETTD DGTTRRTETT VKKVVKTMTT RTVQPVPMGP DGLPVDASAV SNNYIQTLGR 180
DFRKNGNGGP GPYVGQAGTA TLPRNFHYPP DGYGRHYEDG YPGGSDNYGS LSRVTRIEER 240
YRPSMEGYRA PSRQDVYGPQ PQVRVGGSSV DLHRFHPEPY GLEDDQRSMG YDDLDYGMMS 300
DYGTARRTGT PSDPRRRLRS YEDMIGEEVP PDQYYWAPLA QHERGSLASL DSLRKGMPPP 360
SNWRQPELPE VIAMLGFRLD AVKSNAAAYL QHLCYRNDKV KTDVRKLKGI PILVGLLDHP 420
KKEVHLGACG ALKNISFGRD QDNKIAIKNC DGVPALVRLL RKARDMDLTE VITGTLWNLS 480
SHDSIKMEIV DHALHALTDE VIIPHSGWER EPNEDCKPRH IEWESVLTNT AGCLRNVSSE 540
RSEARRKLRE CDGLVDALIF IVQAEIGQKD SDSKLVENCV CLLRNLSYQV HREIPQAERY 600
QEALPTVANS TGPHAASCFG AKKGKDEWFS RGKKPTEDPA NDTVDFPKRT SPARGYELLF 660
QPEVVRIYIS LLKESKTPAI LEASAGAIQN LCAGRWTYGR YIRSALRQEK ALSAIAELLT 720
SEHERVVKAA SGALRNLAVD ARNKELIGKH AIPNLVKNLP GGQQNSSWNF SEDTVVSILN 780
TINEVIAENL EAAKKLRETQ GIEKLVLINK SGNRSEKEVR AAALVLQTIW GYKELRKPLE 840
KEGWKKSDFQ VNLNNASRSQ SSHSYDDSTL PLIDRNQKSD NNYSTLNERG DHNRTLDRSG 900
DLGDMEPLKG APLMQKI 917 
Gene Ontology
 GO:0005913; C:cell-cell adherens junction; IDA:MGI.
 GO:0005737; C:cytoplasm; ISS:UniProtKB.
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0030027; C:lamellipodium; IDA:MGI.
 GO:0030496; C:midbody; ISS:UniProtKB.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0005886; C:plasma membrane; IMP:MGI.
 GO:0016337; P:cell-cell adhesion; IMP:MGI.
 GO:0060690; P:epithelial cell differentiation involved in salivary gland development; IMP:MGI.
 GO:0030216; P:keratinocyte differentiation; IMP:MGI.
 GO:0001738; P:morphogenesis of a polarized epithelium; IMP:MGI.
 GO:0090090; P:negative regulation of canonical Wnt receptor signaling pathway; IEA:Compara.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0007435; P:salivary gland morphogenesis; IMP:MGI.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW. 
Interpro
 IPR011989; ARM-like.
 IPR016024; ARM-type_fold.
 IPR000225; Armadillo. 
Pfam
 PF00514; Arm 
SMART
 SM00185; ARM 
PROSITE
 PS50176; ARM_REPEAT 
PRINTS