| Tag | Content |
|---|
| CPLM ID | CPLM-017614 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Sn1-specific diacylglycerol lipase beta |
Protein Synonyms/Alias | DGL-beta; KCCR13L |
Gene Name | DAGLB |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 167 | RTISGTTKSLPRWSA | ubiquitination | [1] | | 277 | VQDRLAHKGISQAAR | ubiquitination | [1] | | 380 | VTNLEDLKRRILRVV | ubiquitination | [1] | | 499 | SHEAEFSKILIGPKM | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Catalyzes the hydrolysis of diacylglycerol (DAG) to 2- arachidonoyl-glycerol (2-AG), the most abundant endocannabinoid in tissues. Required for axonal growth during development and for retrograde synaptic signaling at mature synapses. |
Sequence Annotation | ACT_SITE 443 443 Charge relay system.
ACT_SITE 495 495 Charge relay system.
MOD_RES 570 570 Phosphoserine.
MOD_RES 574 574 Phosphoserine.
MOD_RES 579 579 Phosphoserine.
MOD_RES 584 584 Phosphoserine. |
Keyword | Alternative splicing; Calcium; Cell membrane; Complete proteome; Hydrolase; Lipid degradation; Lipid metabolism; Membrane; Metal-binding; Phosphoprotein; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 672 AA |
Protein Sequence | MPGMVLFGRR WAIASDDLVF PGFFELVVRV LWWIGILTLY LMHRGKLDCA GGALLSSYLI 60
VLMILLAVVI CTVSAIMCVS MRGTICNPGP RKSMSKLLYI RLALFFPEMV WASLGAAWVA 120
DGVQCDRTVV NGIIATVVVR TQIWCPATLR RASPCFISNR TISGTTKSLP RWSAMPQGAP 180
SCRSRTTDYD LVGGDQLNCH FGSILHTTGL QYRDFIHVSF HDKVYELPFL VALDHRKESV 240
VVAVRGTMSL QDVLTDLSAE SEVLDVECEV QDRLAHKGIS QAARYVYQRL INDGILSQAF 300
SIAPEYRLVI VGHSLGGGAA ALLATMLRAA YPQVRCYAFS PPRGLWSKAL QEYSQSFIVS 360
LVLGKDVIPR LSVTNLEDLK RRILRVVAHC NKPKYKILLH GLWYELFGGN PNNLPTELDG 420
GDQEVLTQPL LGEQSLLTRW SPAYSFSSDS PLDSSPKYPP LYPPGRIIHL QEEGASGRFG 480
CCSAAHYSAK WSHEAEFSKI LIGPKMLTDH MPDILMRALD SVVSDRAACV SCPAQGVSSV 540
DVA 543 |
Gene Ontology | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005886; C:plasma membrane; TAS:Reactome. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0004806; F:triglyceride lipase activity; IEA:InterPro. GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW. GO:0030168; P:platelet activation; TAS:Reactome. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |