CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-007169
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Diacetyl reductase [(R)-acetoin forming] 
Protein Synonyms/Alias
  
Gene Name
 BDH1 
Gene Synonyms/Alias
 BDH; YAL060W; FUN49 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
246NPSKHGHKSIEILRGacetylation[1]
Reference
 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 
Functional Description
 Catalyzes the irreversible reduction of 2,3-butanediol to (S)-acetoin in the presence of NADH (By similarity). 
Sequence Annotation
 METAL 39 39 Zinc 1; catalytic (By similarity).
 METAL 73 73 Zinc 1; catalytic (By similarity).
 METAL 103 103 Zinc 2 (By similarity).
 METAL 120 120 Zinc 2 (By similarity).
 METAL 123 123 Zinc 2 (By similarity).
 METAL 131 131 Zinc 2 (By similarity).
 METAL 173 173 Zinc 1; catalytic (By similarity).
 MOD_RES 63 63 Phosphoserine.  
Keyword
 Complete proteome; Cytoplasm; Metal-binding; NAD; Oxidoreductase; Phosphoprotein; Reference proteome; Zinc. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 382 AA 
Protein Sequence
MRALAYFKKG DIHFTNDIPR PEIQTDDEVI IDVSWCGICG SDLHEYLDGP IFMPKDGECH 60
KLSNAALPLA MGHEMSGIVS KVGPKVTKVK VGDHVVVDAA SSCADLHCWP HSKFYNSKPC 120
DACQRGSENL CTHAGFVGLG VISGGFAEQV VVSQHHIIPV PKEIPLDVAA LVEPLSVTWH 180
AVKISGFKKG SSALVLGAGP IGLCTILVLK GMGASKIVVS EIAERRIEMA KKLGVEVFNP 240
SKHGHKSIEI LRGLTKSHDG FDYSYDCSGI QVTFETSLKA LTFKGTATNI AVWGPKPVPF 300
QPMDVTLQEK VMTGSIGYVV EDFEEVVRAI HNGDIAMEDC KQLITGKQRI EDGWEKGFQE 360
LMDHKESNVK ILLTPNNHGE MK 382 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:SGD.
 GO:0000721; F:(R,R)-butanediol dehydrogenase activity; IDA:SGD.
 GO:0052587; F:diacetyl reductase ((R)-acetoin forming) activity; IEA:EC.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0034079; P:butanediol biosynthetic process; IMP:SGD. 
Interpro
 IPR013149; ADH_C.
 IPR013154; ADH_GroES-like.
 IPR002085; ADH_SF_Zn-type.
 IPR002328; ADH_Zn_CS.
 IPR011032; GroES-like.
 IPR016040; NAD(P)-bd_dom. 
Pfam
 PF08240; ADH_N
 PF00107; ADH_zinc_N 
SMART
  
PROSITE
 PS00059; ADH_ZINC 
PRINTS