UniProt Accession

 RDH11_HUMAN; Q8TC12; A6NDK3; A8K062; B2RB26; B4DDW0; Q6IAH5; Q9NRW0; Q9Y391 

Genbank Protein ID

 AF167438; AF395068; AF151840; CR457180; AK289427; AK293355; AK314465; AK074749; AL049779; CH471061; BC000112; BC011727; BC026274; BC037302; BC051291 

Genbank Nucleotide ID

 AAF89632.1; AAK72049.1; AAD34077.1; CAG33461.1; BAF82116.1; BAG56871.1; BAG37073.1; BAG51997.1; EAW80950.1; AAH00112.1; AAH11727.1; AAH26274.1; AAH37302.1; AAH51291.1 

Protein Name

 Retinol dehydrogenase 11 

Protein Synonyms/Alias

 Androgen-regulated short-chain dehydrogenase/reductase 1; HCV core-binding protein HCBP12; Prostate short-chain dehydrogenase/reductase 1; Retinal reductase 1; RalR1 

Gene Name

 RDH11 

Gene Synonyms/Alias

 ARSDR1; PSDR1; CGI-82 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
70	EKGELVAKEIQTTTG	ubiquitination	[1]
92	KLDLSDTKSIRAFAK	ubiquitination	[1]
99	KSIRAFAKGFLAEEK	ubiquitination	[1]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Exhibits an oxidoreductive catalytic activity towards retinoids. Most efficient as an NADPH-dependent retinal reductase. Displays high activity towards 9-cis and all-trans-retinol. Also involved in the metabolism of short-chain aldehydes. No steroid dehydrogenase activity detected. 

Sequence Annotation

 NP_BIND 48 54 NADP (By similarity).
 ACT_SITE 202 202 Proton acceptor (By similarity).
 BINDING 177 177 Substrate (By similarity).
 MOD_RES 112 112 N6-acetyllysine.  

Keyword

 Acetylation; Alternative splicing; Complete proteome; Endoplasmic reticulum; Membrane; NADP; Oxidoreductase; Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 318 AA 

Protein Sequence

Gene Ontology

 GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0001917; C:photoreceptor inner segment; IEA:Compara.
 GO:0052650; F:NADP-retinol dehydrogenase activity; IDA:MGI.
 GO:0004745; F:retinol dehydrogenase activity; ISS:UniProtKB.
 GO:0016062; P:adaptation of rhodopsin mediated signaling; IEA:Compara.
 GO:0007603; P:phototransduction, visible light; TAS:Reactome.
 GO:0042574; P:retinal metabolic process; IDA:MGI.
 GO:0042572; P:retinol metabolic process; ISS:UniProtKB. 

Interpro

 IPR002198; DH_sc/Rdtase_SDR.
 IPR002347; Glc/ribitol_DH.
 IPR016040; NAD(P)-bd_dom. 

Pfam

 PF00106; adh_short 

SMART

  

PROSITE

 PS00061; ADH_SHORT 

PRINTS

 PR00081; GDHRDH.
 PR00080; SDRFAMILY.