| Tag | Content |
|---|
| CPLM ID | CPLM-014532 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Interleukin-1 receptor accessory protein |
Protein Synonyms/Alias | IL-1 receptor accessory protein; IL-1RAcP |
Gene Name | Il1rap |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 559 | PRWSSSDKQGLSYSS | ubiquitination | [1] |
|
Reference | [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J. J Proteome Res. 2012 Sep 7;11(9):4722-32. [ PMID: 22871113] |
Functional Description | Coreceptor with IL1R1. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Secreted forms (isoforms 2 and 3) associate with secreted ligand-bound IL1R2 and increase the affinity of secreted IL1R2 for IL1B; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors (By similarity). |
Sequence Annotation | DOMAIN 21 128 Ig-like C2-type 1.
DOMAIN 141 230 Ig-like C2-type 2.
DOMAIN 243 348 Ig-like C2-type 3.
DOMAIN 403 549 TIR.
MOD_RES 395 395 Phosphothreonine (By similarity).
MOD_RES 398 398 Phosphothreonine (By similarity).
MOD_RES 557 557 Phosphoserine (By similarity).
CARBOHYD 57 57 N-linked (GlcNAc...) (Potential).
CARBOHYD 107 107 N-linked (GlcNAc...) (Potential).
CARBOHYD 111 111 N-linked (GlcNAc...) (Potential).
CARBOHYD 118 118 N-linked (GlcNAc...) (Potential).
CARBOHYD 157 157 N-linked (GlcNAc...) (Potential).
CARBOHYD 196 196 N-linked (GlcNAc...) (Potential).
CARBOHYD 209 209 N-linked (GlcNAc...) (Potential).
DISULFID 24 122 By similarity.
DISULFID 47 114 By similarity.
DISULFID 137 181 By similarity.
DISULFID 160 212 By similarity.
DISULFID 266 332 By similarity. |
Keyword | Complete proteome; Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane; Phosphoprotein; Receptor; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 570 AA |
Protein Sequence | MGLPWCLMSL FFCGILQSHA SERCDDWGLD TMRQIQVFED EPARIKCPLF EHFLKYNYST 60
AHSSGLTLIW YWTRQDRDLE EPINFRLPEN RISKEKDVLW FRPTLLNDTG NYTCMLRNTT 120
YCSKVAFPLE VVQKDSCFNS PMRLPVHRLY IEQGIHNITC PNVDGYFPSS VKPSVTWYKG 180
CTEIVNFHNV QPKGMNLSFF IPLVSNNGNY TCVVTYLENG RLFHLTRTMT VKVVGSPKDA 240
VPPHIYSPND RVVYEKEPGE ELVIPCKVYF SFIMDSHNEI WWTIDGKKPD DVPVDITIIE 300
SVSYSSTEDE TRTQILSIKK VTPEDLKRNY VCHARNAEGE AEQAAKVKQK VIPPRYTVEL 360
ACGFGATVFL VVVLIVVYHV YWLEMVLFYR AHFGTDETIL DGKEYDIYVS YARNAEEEEF 420
VLLTLRGVLE NEFGYKLCIF DRDSFPGGIV TDETLSFIQK SRRLLVVLSP NYVLQGTQAL 480
LELKAGLENM ASRGNINVIL VQYKAVKDLK VKELKRAKSV LTVIKWKGEK SKYPQGRFWK 540
QLQVAMPVKK SPRWSSSDKQ GLSYSSLKNV 570 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |