UniProt Accession

 QOR_RAT; Q6AYT0 

Genbank Protein ID

 BC078927 

Genbank Nucleotide ID

 AAH78927.1 

Protein Name

 Quinone oxidoreductase 

Protein Synonyms/Alias

 NADPH:quinone reductase; Zeta-crystallin 

Gene Name

 Cryz 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
6	**MATGQKLMRAIRV	acetylation	[1]
23	FGGPEVLKLQSDVVV	acetylation	[1]
88	GDGVSAFKKGDRVFC	acetylation	[1]
175	IARAHGLKVLGTAGS	acetylation	[1]
186	TAGSEEGKKLVLQNG	acetylation	[1]
187	AGSEEGKKLVLQNGA	acetylation	[1]
201	AHEVFNHKEANYIDK	acetylation	[1]
208	KEANYIDKIKTSAGD	acetylation	[1]
210	ANYIDKIKTSAGDKG	acetylation	[1]
216	IKTSAGDKGVDVIIE	acetylation	[1]
228	IIEMLANKNLSNDLK	acetylation	[1]
235	KNLSNDLKLLSCGGR	acetylation	[1]
296	GIEKGWVKPVIGSEY	acetylation	[1]
307	GSEYPLEKAAQAHED	acetylation	[1]
321	DIIHSSGKMGKMILL	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Does not have alcohol dehydrogenase activity. Binds NADP and acts through a one-electron transfer process. Orthoquinones, such as 1,2-naphthoquinone or 9,10-phenanthrenequinone, are the best substrates (in vitro). May act in the detoxification of xenobiotics. Interacts with (AU)-rich elements (ARE) in the 3'-UTR of target mRNA species and enhances their stability. NADPH binding interferes with mRNA binding (By similarity). 

Sequence Annotation

 NP_BIND 158 161 NADP (By similarity).
 NP_BIND 246 249 NADP (By similarity).
 NP_BIND 269 271 NADP (By similarity).
 BINDING 53 53 NADP (By similarity).
 BINDING 181 181 NADP; via amide nitrogen (By similarity).
 BINDING 200 200 NADP (By similarity).
 BINDING 229 229 NADP (By similarity).
 MOD_RES 23 23 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Complete proteome; Cytoplasm; NADP; Oxidoreductase; Reference proteome; RNA-binding. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 329 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; ISS:UniProtKB.
 GO:0005794; C:Golgi apparatus; IEA:Compara.
 GO:0003730; F:mRNA 3'-UTR binding; ISS:UniProtKB.
 GO:0070402; F:NADPH binding; ISS:UniProtKB.
 GO:0003960; F:NADPH:quinone reductase activity; ISS:UniProtKB.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0051289; P:protein homotetramerization; IEA:Compara.
 GO:0042178; P:xenobiotic catabolic process; ISS:UniProtKB. 

Interpro

 IPR013149; ADH_C.
 IPR013154; ADH_GroES-like.
 IPR002085; ADH_SF_Zn-type.
 IPR011032; GroES-like.
 IPR016040; NAD(P)-bd_dom.
 IPR002364; Quin_OxRdtase/zeta-crystal_CS. 

Pfam

 PF08240; ADH_N
 PF00107; ADH_zinc_N 

SMART

  

PROSITE

 PS01162; QOR_ZETA_CRYSTAL 

PRINTS