UniProt Accession

 ZBT25_HUMAN; P24278; B3KUX6; Q8IYH9 

Genbank Protein ID

 X16576; AK098181; CH471061; BC035804 

Genbank Nucleotide ID

 CAA34595.1; BAG53588.1; EAW80861.1; AAH35804.1 

Protein Name

 Zinc finger and BTB domain-containing protein 25 

Protein Synonyms/Alias

 Zinc finger protein 46; Zinc finger protein KUP 

Gene Name

 ZBTB25 

Gene Synonyms/Alias

 C14orf51; KUP; ZNF46 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
142	TTQKTVVKQGLEVKE	ubiquitination	[1]
148	VKQGLEVKEAPSSNS	ubiquitination	[1, 2]
303	RLSSFIVKENEQQPD	ubiquitination	[1]
374	HMYTHKGKSYRYNRC	ubiquitination	[1]
405	SWSDVSLKSSRLSQE	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 May be involved in transcriptional regulation. 

Sequence Annotation

 DOMAIN 1 107 BTB.
 ZN_FING 238 260 C2H2-type 1.
 ZN_FING 349 371 C2H2-type 2.  

Keyword

 Complete proteome; DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 435 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IDA:UniProtKB.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; TAS:ProtInc.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0010467; P:gene expression; IEP:UniProtKB.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR000210; BTB/POZ-like.
 IPR011333; BTB/POZ_fold.
 IPR013069; BTB_POZ.
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 

Pfam

 PF00651; BTB
 PF00096; zf-C2H2 

SMART

 SM00225; BTB
 SM00355; ZnF_C2H2 

PROSITE

 PS50097; BTB
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 

PRINTS